DegronMD - P35611(ADD1)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G425C	TCGA-60-2714	LUSC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.3056
p.G425C	TCGA-D3-A2JB	SKCM	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.3056
p.G425C	DO26530	LUSC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.3056
p.G425C	DO47607	SKCM	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.3056
p.Q438H	TCGA-60-2714	LUSC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.1389
p.Q438H	DO26530	LUSC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.1389
p.D426N	TCGA-A2-A0SY	BRCA	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.6932
p.D426N	TCGA-Q1-A73P	CESC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.6932
p.D426N	DO2961	BRCA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.6932
p.D426N	DO49983	CESC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.6932
p.D634Y	TCGA-AP-A1DV	UCEC	TCGA	EEDLVPEP	DEG_COP1_1	619:626	Mutation rewiring degron network	0.1111
p.S427P	TCGA-B5-A1MX	UCEC	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.7863
p.S427P	DO41999	UCEC	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.7863
p.P432T	TCGA-EE-A2A5	SKCM	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.3056
p.P432T	DO37941	SKCM	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.3056
p.E619D	TCGA-FD-A43P	BLCA	TCGA	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.5647
p.Q438R	TCGA-YD-A9TA	SKCM	TCGA	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.1389
p.Q438R	DO219503	SKCM	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.1389
p.P610L	DO222576	COCA	ICGC	EEDLVPEP	DEG_COP1_1	619:626	Mutation rewiring degron network	0.0833
p.T627I	DO222837	MELA	ICGC	EEDLVPEP	DEG_COP1_1	619:626	Mutation rewiring degron network	0.3056
p.T627N	DO50723	ORCA	ICGC	EEDLVPEP	DEG_COP1_1	619:626	Mutation rewiring degron network	0.3056
p.Y419H	DO228017	SKCA	ICGC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation rewiring degron network	0.1389
p.S427L	SIDM00148	Breast Carcinoma	GDSC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.8778
p.S427L	ACH-000019	Breast Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.8778
p.S427L	ACH-000028	Breast Cancer	CCLE	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.8778
p.S427L	MCF7	breast	COSMIC	DSGTCS	DEG_SCF_TRCP1_1	426:431	Mutation altering degron motif	0.8778
p.K613R	SIDM01695	Acute Myeloid Leukemia	GDSC	EEDLVPEP	DEG_COP1_1	619:626	Mutation blocking phosphorylation signal	0.6111
p.K613R	ACH-000166	Leukemia	CCLE	EEDLVPEP	DEG_COP1_1	619:626	Mutation blocking phosphorylation signal	0.6111
p.E626K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.7022
p.L622H	ACH-000316	Liver Cancer	CCLE	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.6202
p.L622H	KINGS-1	central nervous system	COSMIC	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.6202
p.V623L	ACH-000316	Liver Cancer	CCLE	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.6765
p.V623L	KINGS-1	central nervous system	COSMIC	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.6765
p.E619Q	TT2609-C02	thyroid	COSMIC	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.6744
p.L630P	SNU-C5	large intestine	COSMIC	EEDLVPEP	DEG_COP1_1	619:626	Mutation rewiring degron network	0.2222
p.A626S	OVTOKO	ovary	COSMIC	EEDLVPEP	DEG_COP1_1	619:626	Mutation altering degron motif	0.7588

Kaplan plot for ADD1 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADD1

UniProt ID: P35611

Entrez ID: 118

Protein name: Alpha-adducin (Erythrocyte adducin subunit alpha)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ADD1 in