DegronMD

Uniprot ID: P35611

Source protein: Alpha-adducin

Source gene: ADD1

Class: DEG_COP1_1

Location: 619:626

E3 ligase: COP1

DEGRON score: 0.9915

ASA_SCORE: 102.575

COIL: 0.8333

CONS_SCORE: 0.3294

DSS_SCORE: 0.841

HELIX: 0.1634

FCONS_SCORE: 0.9968

RIG_SCORE: 0.6488

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D634Y	TCGA-AP-A1DV	UCEC	TCGA	EEDLVPEP	DEG_COP1_1	0.1111
p.E619D	TCGA-FD-A43P	BLCA	TCGA	EEDLVPEP	DEG_COP1_1	0.5647
p.P610L	DO222576	COCA	ICGC	EEDLVPEP	DEG_COP1_1	0.0833
p.T627I	DO222837	MELA	ICGC	EEDLVPEP	DEG_COP1_1	0.3056
p.T627N	DO50723	ORCA	ICGC	EEDLVPEP	DEG_COP1_1	0.3056
p.K613R	SIDM01695	Acute Myeloid Leukemia	GDSC	EEDLVPEP	DEG_COP1_1	0.6111
p.K613R	ACH-000166	Leukemia	CCLE	EEDLVPEP	DEG_COP1_1	0.6111
p.E626K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	EEDLVPEP	DEG_COP1_1	0.7022
p.L622H	ACH-000316	Liver Cancer	CCLE	EEDLVPEP	DEG_COP1_1	0.6202
p.L622H	KINGS-1	central_nervous_system	COSMIC	EEDLVPEP	DEG_COP1_1	0.6202
p.V623L	ACH-000316	Liver Cancer	CCLE	EEDLVPEP	DEG_COP1_1	0.6765
p.V623L	KINGS-1	central_nervous_system	COSMIC	EEDLVPEP	DEG_COP1_1	0.6765
p.E619Q	TT2609-C02	thyroid	COSMIC	EEDLVPEP	DEG_COP1_1	0.6744
p.L630P	SNU-C5	large_intestine	COSMIC	EEDLVPEP	DEG_COP1_1	0.2222
p.A626S	OVTOKO	ovary	COSMIC	EEDLVPEP	DEG_COP1_1	0.7588

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P35611	Alpha-adducin	DEG_COP1_1	619:626	EEDLVPEP	COP1	0.9915	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons