DegronMD

Uniprot ID: P49639

Source protein: Homeobox protein Hox-A1

Source gene: HOXA1

Class: DEG_COP1_1

Location: 314:323

E3 ligase: COP1

DEGRON score: 0.9688

ASA_SCORE: 101.5

COIL: 0.9809

CONS_SCORE: 0.5305

DSS_SCORE: 0.7051

HELIX: 0.0128

FCONS_SCORE: 1.1645

RIG_SCORE: 0.5085

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P321H	TCGA-55-7910	LUAD	TCGA	SSSSPCVPSP	DEG_COP1_1	0.7694
p.P321H	DO23669	LUAD	ICGC	SSSSPCVPSP	DEG_COP1_1	0.7694
p.T330S	TCGA-78-7147	LUAD	TCGA	SSSSPCVPSP	DEG_COP1_1	0.1389
p.T330S	DO24527	LUAD	ICGC	SSSSPCVPSP	DEG_COP1_1	0.1389
p.T333I	TCGA-A5-A1OF	UCEC	TCGA	SSSSPCVPSP	DEG_COP1_1	0.0556
p.T333I	DO42568	UCEC	ICGC	SSSSPCVPSP	DEG_COP1_1	0.0556
p.E312D	TCGA-AJ-A3EL	UCEC	TCGA	SSSSPCVPSP	DEG_COP1_1	0.2778
p.E312D	DO41542	UCEC	ICGC	SSSSPCVPSP	DEG_COP1_1	0.2778
p.S316Y	TCGA-BS-A0UJ	UCEC	TCGA	SSSSPCVPSP	DEG_COP1_1	0.6009
p.S316Y	DO42745	UCEC	ICGC	SSSSPCVPSP	DEG_COP1_1	0.6009
p.S316Y	SIDM01611	Endometrial Carcinoma	GDSC	SSSSPCVPSP	DEG_COP1_1	0.6009
p.S316Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	0.6009
p.E308K	TCGA-CV-7102	HNSC	TCGA	SSSSPCVPSP	DEG_COP1_1	0.1667
p.E308K	DO14194	HNSC	ICGC	SSSSPCVPSP	DEG_COP1_1	0.1667
p.T330I	TCGA-DH-A7UR	LGG	TCGA	SSSSPCVPSP	DEG_COP1_1	0.1389
p.T330I	DO51809	LGG	ICGC	SSSSPCVPSP	DEG_COP1_1	0.1389
p.S322P	DO227854	BRCA	ICGC	SSSSPCVPSP	DEG_COP1_1	0.6752
p.S322Y	DO229026	LICA	ICGC	SSSSPCVPSP	DEG_COP1_1	0.712
p.E309K	DO220894	MELA	ICGC	SSSSPCVPSP	DEG_COP1_1	0.1944
p.D304G	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SSSSPCVPSP	DEG_COP1_1	0.0556
p.D304G	ACH-002256	Leukemia	CCLE	SSSSPCVPSP	DEG_COP1_1	0.0556
p.D304G	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SSSSPCVPSP	DEG_COP1_1	0.0556
p.V320I	SIDM00342	T-Lymphoblastic Leukemia	GDSC	SSSSPCVPSP	DEG_COP1_1	0.7076
p.V320I	ACH-000104	Leukemia	CCLE	SSSSPCVPSP	DEG_COP1_1	0.7076
p.V320I	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	SSSSPCVPSP	DEG_COP1_1	0.7076
p.S317L	ACH-000681	Lung Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	0.6556
p.S317L	ACH-001201	Brain Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	0.6556
p.P318H	ACH-000868	Lung Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	0.6583
p.S314P	ACH-000999	Colon/Colorectal Cancer	CCLE	SSSSPCVPSP	DEG_COP1_1	0.6752
p.S314P	SNU-1040	large_intestine	COSMIC	SSSSPCVPSP	DEG_COP1_1	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SSSSPCVPSP

Degron related mutations and impact score

Drug responses associated with HOXA1 mutations

All proteins holding degron of SSSSPCVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P49639	Homeobox protein Hox-A1	DEG_COP1_1	314:323	SSSSPCVPSP	COP1	0.9688	More...