DegronMD

Uniprot ID: Q14541

Source protein: Hepatocyte nuclear factor 4-gamma

Source gene: HNF4G

Class: DEG_SPOP_SBC_1

Location: 122:126

E3 ligase: SPOP

DEGRON score: 0.5473

ASA_SCORE: 72.98

COIL: 0.93

CONS_SCORE: 0.3767

DSS_SCORE: 0.388

HELIX: 0.0446

FCONS_SCORE: 0.7371

RIG_SCORE: 0.6012

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A112V	TCGA-77-7142	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	0.0556
p.A112V	DO26462	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	0.0556
p.D134V	TCGA-AB-2922	LAML	TCGA	PGSST	DEG_SPOP_SBC_1	0.1111
p.D134V	DO21427	LAML	ICGC	PGSST	DEG_SPOP_SBC_1	0.1111
p.E117G	TCGA-BR-8361	STAD	TCGA	PGSST	DEG_SPOP_SBC_1	0.1944
p.E117G	DO48032	STAD	ICGC	PGSST	DEG_SPOP_SBC_1	0.1944
p.M114I	TCGA-DA-A960	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.1111
p.M114I	TCGA-YG-AA3N	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.1111
p.M114I	DO51298	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.1111
p.M114I	DO219482	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.1111
p.G113R	TCGA-EB-A44P	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.0833
p.G113R	DO222837	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	0.0833
p.G113R	DO47525	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.0833
p.G113R	SIDM00927	Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	0.0833
p.G113R	ACH-000871	Lung Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	0.0833
p.G113R	NCI-H510A	lung	COSMIC	PGSST	DEG_SPOP_SBC_1	0.0833
p.R125K	TCGA-EB-A5UN	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.7237
p.R125K	TCGA-OD-A75X	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.7237
p.R125K	DO47267	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.7237
p.R125K	DO48601	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.7237
p.A112T	TCGA-EE-A3AA	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	0.0556
p.A112T	DO222632	MELA	ICGC	PGSST	DEG_SPOP_SBC_1	0.0556
p.A112T	DO37571	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	0.0556
p.R125S	TCGA-FA-A82F	DLBC	TCGA	PGSST	DEG_SPOP_SBC_1	0.7427
p.R125S	DO219891	DLBC	ICGC	PGSST	DEG_SPOP_SBC_1	0.7427
p.D124Y	TCGA-KQ-A41N	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	0.7325
p.D124Y	DO223588	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	0.7325
p.R125I	TCGA-KQ-A41Q	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	0.8102
p.R125I	DO223591	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	0.8102
p.R123H	DO233245	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	0.8244
p.K115E	DO233270	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	0.1389
p.R123L	DO229029	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	0.8428
p.G113E	DO48723	LIRI	ICGC	PGSST	DEG_SPOP_SBC_1	0.0833
p.E117D	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	0.1944
p.E117D	NCI-H2342	lung	COSMIC	PGSST	DEG_SPOP_SBC_1	0.1944
p.R130K	SIDM00118	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	0.2222
p.R130K	ACH-001081	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	0.2222
p.R130K	HCC2998	large_intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15061	Synemin	DEG_SPOP_SBC_1	1302:1306	PGSST	SPOP	0.9781	More...
O60741	Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1	DEG_SPOP_SBC_1	758:762	PGSST	SPOP	0.9855	More...
O94875	Sorbin and SH3 domain-containing protein 2	DEG_SPOP_SBC_1	285:289	PGSST	SPOP	0.99	More...
O95665	Neurotensin receptor type 2	DEG_SPOP_SBC_1	246:250	PGSST	SPOP	0.8617	More...
P17948	Vascular endothelial growth factor receptor 1	DEG_SPOP_SBC_1	711:715	PGSST	SPOP	0.6649	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	477:481	PGSST	SPOP	0.7875	More...
P49639	Homeobox protein Hox-A1	DEG_SPOP_SBC_1	323:327	PGSST	SPOP	0.9865	More...
P52799	Ephrin-B2	DEG_SPOP_SBC_1	204:208	PGSST	SPOP	0.573	More...
Q13164	Mitogen-activated protein kinase 7	DEG_SPOP_SBC_1	676:680	PGSST	SPOP	0.9143	More...
Q14541	Hepatocyte nuclear factor 4-gamma	DEG_SPOP_SBC_1	122:126	PGSST	SPOP	0.5473	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	759:763	PGSST	SPOP	0.9962	More...
Q5W0B1	ORC ubiquitin ligase 1	DEG_SPOP_SBC_1	302:306	PGSST	SPOP	0.9546	More...
Q7Z5P9	Mucin-19	DEG_SPOP_SBC_1	1949:1953	PGSST	SPOP	0.9296	More...
Q86UW9	Probable E3 ubiquitin-protein ligase DTX2	DEG_SPOP_SBC_1	294:298	PGSST	SPOP	0.9802	More...
Q8IVI9	Nostrin	DEG_SPOP_SBC_1	426:430	PGSST	SPOP	0.6311	More...
Q8TER5	Rho guanine nucleotide exchange factor 40	DEG_SPOP_SBC_1	1488:1492	PGSST	SPOP	0.9989	More...
Q96HA1	Nuclear envelope pore membrane protein POM 121	DEG_SPOP_SBC_1	1118:1122	PGSST	SPOP	0.981	More...
Q96L96	Alpha-protein kinase 3	DEG_SPOP_SBC_1	77:81	PGSST	SPOP	0.9946	More...
Q96M63	Outer dynein arm-docking complex subunit 1	DEG_SPOP_SBC_1	660:664	PGSST	SPOP	0.9788	More...
Q9NZB2	Constitutive coactivator of PPAR-gamma-like protein 1	DEG_SPOP_SBC_1	454:458	PGSST	SPOP	0.9977	More...
Q9UKD1	Glucocorticoid modulatory element-binding protein 2	DEG_SPOP_SBC_1	495:499	PGSST	SPOP	0.6991	More...
Q9UPT9	Ubiquitin carboxyl-terminal hydrolase 22	DEG_SPOP_SBC_1	332:336	PGSST	SPOP	0.9585	More...
Q9UQC2	GRB2-associated-binding protein 2	DEG_SPOP_SBC_1	457:461	PGSST	SPOP	0.9866	More...
O75956	Cyclin-dependent kinase 2-associated protein 2	DEG_SPOP_SBC_1	14:18	PGSST	SPOP	0.9967	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	386:390	PGSST	SPOP	0.948	More...
Q9C0E2	Exportin-4	DEG_SPOP_SBC_1	522:526	PGSST	SPOP	0.9799	More...
Q8NDD1	Uncharacterized protein C1orf131	DEG_SPOP_SBC_1	17:21	PGSST	SPOP	0.968	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1572:1576	PGSST	SPOP	0.9337	More...
Q9ULL5	Proline-rich protein 12	DEG_SPOP_SBC_1	137:141	PGSST	SPOP	0.967	More...
Q5T035	Putative uncharacterized protein C9orf129	DEG_SPOP_SBC_1	103:107	PGSST	SPOP	0.9971	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGSST

Degron related mutations and impact score

Drug responses associated with HNF4G mutations

All proteins holding degron of PGSST