DegronMD - Q9UKD1(GMEB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V6M	TCGA-57-1993	OV	TCGA	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6097
p.V6M	DO230311	COCA	ICGC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6097
p.V6M	DO30910	OV	ICGC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6097
p.V6M	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6097
p.V6M	ACH-000563	Lung Cancer	CCLE	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6097
p.V6M	EBC-1	lung	COSMIC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.6097
p.S494L	TCGA-75-6214	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.S494L	TCGA-78-7158	LUAD	TCGA	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.S494L	TCGA-MF-A522	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.S494L	DO218136	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.S494L	DO24729	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.S494L	DO24830	LUAD	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.S494L	DO45526	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.3056
p.P504S	TCGA-D1-A1O7	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1944
p.P504S	DO41139	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1944
p.E11D	TCGA-ER-A19P	SKCM	TCGA	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.2222
p.E11D	DO47623	SKCM	ICGC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.2222
p.T17A	TCGA-F4-6808	COAD	TCGA	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.0556
p.T17A	DO8946	COAD	ICGC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.0556
p.A505T	TCGA-G4-6323	COAD	TCGA	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.A505T	DO9138	COAD	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.A505T	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.A505T	ACH-001738	Leukemia	CCLE	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.A505T	CCRF-CEM	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.D5N	DO228935	COCA	ICGC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.5821
p.V13M	DO222840	COCA	ICGC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation rewiring degron network	0.1667
p.A505V	DO233760	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.1667
p.T486I	DO233823	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0833
p.T502K	DO229032	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.25
p.T486S	DO23490	LINC	ICGC	PGSST	DEG_SPOP_SBC_1	495:499	Mutation rewiring degron network	0.0833
p.A2V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.5825
p.A2V	ACH-001127	Leukemia	CCLE	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.5825
p.A2V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	MATPDVS	DEG_SCF_FBW7_1	1:7	Mutation altering degron motif	0.5825

Kaplan plot for GMEB2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GMEB2

UniProt ID: Q9UKD1

Entrez ID: 26205

Protein name: Glucocorticoid modulatory element-binding protein 2 (GMEB-2) (DNA-binding protein p79PIF) (Parvovirus initiation factor p79) (PIF p79)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GMEB2 in