DegronMD

Uniprot ID: Q9UKD1

Source protein: Glucocorticoid modulatory element-binding protein 2

Source gene: GMEB2

Class: DEG_SCF_FBW7_1

Location: 1:7

E3 ligase: FBXW7

DEGRON score: 0.5607

ASA_SCORE: 90.5

COIL: 0.8104

CONS_SCORE: 0.4379

DSS_SCORE: 0.7672

HELIX: 0.0174

FCONS_SCORE: 0.9424

RIG_SCORE: 0.7348

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V6M	TCGA-57-1993	OV	TCGA	MATPDVS	DEG_SCF_FBW7_1	0.6097
p.V6M	DO230311	COCA	ICGC	MATPDVS	DEG_SCF_FBW7_1	0.6097
p.V6M	DO30910	OV	ICGC	MATPDVS	DEG_SCF_FBW7_1	0.6097
p.V6M	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	MATPDVS	DEG_SCF_FBW7_1	0.6097
p.V6M	ACH-000563	Lung Cancer	CCLE	MATPDVS	DEG_SCF_FBW7_1	0.6097
p.V6M	EBC-1	lung	COSMIC	MATPDVS	DEG_SCF_FBW7_1	0.6097
p.E11D	TCGA-ER-A19P	SKCM	TCGA	MATPDVS	DEG_SCF_FBW7_1	0.2222
p.E11D	DO47623	SKCM	ICGC	MATPDVS	DEG_SCF_FBW7_1	0.2222
p.T17A	TCGA-F4-6808	COAD	TCGA	MATPDVS	DEG_SCF_FBW7_1	0.0556
p.T17A	DO8946	COAD	ICGC	MATPDVS	DEG_SCF_FBW7_1	0.0556
p.D5N	DO228935	COCA	ICGC	MATPDVS	DEG_SCF_FBW7_1	0.5821
p.V13M	DO222840	COCA	ICGC	MATPDVS	DEG_SCF_FBW7_1	0.1667
p.A2V	SIDM00145	T-Lymphoblastic Leukemia	GDSC	MATPDVS	DEG_SCF_FBW7_1	0.5825
p.A2V	ACH-001127	Leukemia	CCLE	MATPDVS	DEG_SCF_FBW7_1	0.5825
p.A2V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MATPDVS	DEG_SCF_FBW7_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKD1	Glucocorticoid modulatory element-binding protein 2	DEG_SCF_FBW7_1	1:7	MATPDVS	FBXW7	0.5607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons