DegronMD - Q8TER5(ARHGEF40)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q621E	TCGA-55-6968	LUAD	TCGA	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.2222
p.Q621E	DO23759	LUAD	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.2222
p.R622Q	TCGA-A5-A0G2	UCEC	TCGA	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.25
p.R622Q	DO41235	UCEC	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.25
p.R622Q	SIDM00592	Oral Cavity Carcinoma	GDSC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.25
p.R622Q	ACH-002244	Head and Neck Cancer	CCLE	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.25
p.R622Q	HO-1-N-1	salivary gland	COSMIC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.25
p.L631I	TCGA-AA-A01P	COAD	TCGA	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.3056
p.L631I	DO8642	COAD	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.3056
p.Q1484K	TCGA-CV-6961	HNSC	TCGA	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.2222
p.Q1484K	DO14566	HNSC	ICGC	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.2222
p.R1062Q	TCGA-D1-A2G0	UCEC	TCGA	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062Q	DO43049	UCEC	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062Q	SIDM00281	Other Solid Cancers	GDSC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062Q	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062Q	SIDM01526	Mesothelioma	GDSC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062Q	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062Q	DJM-1	skin	COSMIC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1079H	TCGA-D5-6530	COAD	TCGA	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.3056
p.R1079H	DO8312	COAD	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.3056
p.R1079H	SIDM01460	Glioma	GDSC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.3056
p.R1079H	ACH-000592	Brain Cancer	CCLE	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.3056
p.G1073C	TCGA-DI-A1BU	UCEC	TCGA	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation altering degron motif	0.6489
p.G1073C	DO42023	UCEC	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation altering degron motif	0.6489
p.L1495M	TCGA-DK-A2I1	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.25
p.L1495M	DO444	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.25
p.L619R	TCGA-EO-A22X	UCEC	TCGA	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1667
p.L619R	DO43907	UCEC	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1667
p.R1062L	TCGA-GS-A9TT	DLBC	TCGA	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062L	DO219912	DLBC	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.D509H	TCGA-Q2-A5QZ	KIRP	TCGA	PTPPLE	DEG_SCF_FBW7_2	496:501	Mutation rewiring degron network	0.1111
p.D509H	DO48502	KIRP	ICGC	PTPPLE	DEG_SCF_FBW7_2	496:501	Mutation rewiring degron network	0.1111
p.P617L	TCGA-YG-AA3N	SKCM	TCGA	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1111
p.P617L	DO51298	SKCM	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.1111
p.D616N	DO228276	BRCA	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0833
p.A1085S	DO228976	LICA	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.1389
p.G640C	DO229026	LICA	ICGC	ILIHDD	LIG_APCC_ABBA_1	625:630	Mutation rewiring degron network	0.0556
p.A1063D	DO49199	PACA	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0833
p.N1479H	DO232224	PBCA	ICGC	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.0833
p.R1079C	DO232224	PBCA	ICGC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.3056
p.P491S	SIDM00923	Cervical Carcinoma	GDSC	PTPPLE	DEG_SCF_FBW7_2	496:501	Mutation rewiring degron network	0.1944
p.R1498Q	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.1667
p.S1491N	SIDM00382	Glioblastoma	GDSC	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation altering degron motif	0.818
p.S1491N	ACH-000609	Brain Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation altering degron motif	0.818
p.S1491N	SF126	central nervous system	COSMIC	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation altering degron motif	0.818
p.R1062W	SIDM01051	Ovarian Carcinoma	GDSC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062W	ACH-000936	Ovarian Cancer	CCLE	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.R1062W	EFO-27	ovary	COSMIC	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.0556
p.P499L	SIDM01608	Endometrial Carcinoma	GDSC	PTPPLE	DEG_SCF_FBW7_2	496:501	Mutation altering degron motif	0.6471
p.P499L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPLE	DEG_SCF_FBW7_2	496:501	Mutation altering degron motif	0.6471
p.R1081Q	ACH-000824	Esophageal Cancer	CCLE	VGTPRME	DEG_SCF_FBW7_2	1072:1078	Mutation rewiring degron network	0.25
p.L1495P	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1488:1492	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ARHGEF40

UniProt ID: Q8TER5

Entrez ID: 55701

Protein name: Rho guanine nucleotide exchange factor 40 (Protein SOLO)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ARHGEF40 in