DegronMD

Uniprot ID: Q8TER5

Source protein: Rho guanine nucleotide exchange factor 40

Source gene: ARHGEF40

Class: LIG_APCC_ABBA_1

Location: 625:630

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.501

ASA_SCORE: 60.5333

COIL: 0.6

CONS_SCORE: 0.2805

DSS_SCORE: 0.1079

HELIX: 0.0335

FCONS_SCORE: 0.8908

RIG_SCORE: 0.8781

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q621E	TCGA-55-6968	LUAD	TCGA	ILIHDD	LIG_APCC_ABBA_1	0.2222
p.Q621E	DO23759	LUAD	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.2222
p.R622Q	TCGA-A5-A0G2	UCEC	TCGA	ILIHDD	LIG_APCC_ABBA_1	0.25
p.R622Q	DO41235	UCEC	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.25
p.R622Q	SIDM00592	Oral Cavity Carcinoma	GDSC	ILIHDD	LIG_APCC_ABBA_1	0.25
p.R622Q	ACH-002244	Head and Neck Cancer	CCLE	ILIHDD	LIG_APCC_ABBA_1	0.25
p.R622Q	HO-1-N-1	salivary_gland	COSMIC	ILIHDD	LIG_APCC_ABBA_1	0.25
p.L631I	TCGA-AA-A01P	COAD	TCGA	ILIHDD	LIG_APCC_ABBA_1	0.3056
p.L631I	DO8642	COAD	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.3056
p.L619R	TCGA-EO-A22X	UCEC	TCGA	ILIHDD	LIG_APCC_ABBA_1	0.1667
p.L619R	DO43907	UCEC	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.1667
p.P617L	TCGA-YG-AA3N	SKCM	TCGA	ILIHDD	LIG_APCC_ABBA_1	0.1111
p.P617L	DO51298	SKCM	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.1111
p.D616N	DO228276	BRCA	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.0833
p.G640C	DO229026	LICA	ICGC	ILIHDD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TER5	Rho guanine nucleotide exchange factor 40	LIG_APCC_ABBA_1	625:630	ILIHDD	APC,CDC20,FZR1	0.501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons