DegronMD

Uniprot ID: Q8TER5

Source protein: Rho guanine nucleotide exchange factor 40

Source gene: ARHGEF40

Class: DEG_SCF_FBW7_2

Location: 496:501

E3 ligase: FBXW7

DEGRON score: 0.9962

ASA_SCORE: 83.3333

COIL: 0.8987

CONS_SCORE: 0.3932

DSS_SCORE: 0.8248

HELIX: 0.0335

FCONS_SCORE: 1.5482

RIG_SCORE: 0.6578

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D509H	TCGA-Q2-A5QZ	KIRP	TCGA	PTPPLE	DEG_SCF_FBW7_2	0.1111
p.D509H	DO48502	KIRP	ICGC	PTPPLE	DEG_SCF_FBW7_2	0.1111
p.P491S	SIDM00923	Cervical Carcinoma	GDSC	PTPPLE	DEG_SCF_FBW7_2	0.1944
p.P499L	SIDM01608	Endometrial Carcinoma	GDSC	PTPPLE	DEG_SCF_FBW7_2	0.6471
p.P499L	ACH-000990	Endometrial/Uterine Cancer	CCLE	PTPPLE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13316	Dentin matrix acidic phosphoprotein 1	DEG_SCF_FBW7_2	41:46	PTPPLE	FBXW7	0.9202	More...
Q8TER5	Rho guanine nucleotide exchange factor 40	DEG_SCF_FBW7_2	496:501	PTPPLE	FBXW7	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons