DegronMD

Uniprot ID: Q13316

Source protein: Dentin matrix acidic phosphoprotein 1

Source gene: DMP1

Class: DEG_SCF_FBW7_2

Location: 41:46

E3 ligase: FBXW7

DEGRON score: 0.9202

ASA_SCORE: 102.2167

COIL: 0.9328

CONS_SCORE: 0.5822

DSS_SCORE: 0.748

HELIX: 0.0503

FCONS_SCORE: 0.7898

RIG_SCORE: 0.5671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E31K	TCGA-DA-A95Y	SKCM	TCGA	PTPPLE	DEG_SCF_FBW7_2	0.0556
p.E31K	DO23398	LINC	ICGC	PTPPLE	DEG_SCF_FBW7_2	0.0556
p.E31K	DO223908	SKCM	ICGC	PTPPLE	DEG_SCF_FBW7_2	0.0556
p.E31K	SIDM00505	Pancreatic Carcinoma	GDSC	PTPPLE	DEG_SCF_FBW7_2	0.0556
p.E31K	MIA-PaCa-2	pancreas	COSMIC	PTPPLE	DEG_SCF_FBW7_2	0.0556
p.K55N	TCGA-FF-8042	DLBC	TCGA	PTPPLE	DEG_SCF_FBW7_2	0.1944
p.K55N	DO222306	DLBC	ICGC	PTPPLE	DEG_SCF_FBW7_2	0.1944
p.G35D	TCGA-FR-A726	SKCM	TCGA	PTPPLE	DEG_SCF_FBW7_2	0.1667
p.G35D	DO48665	SKCM	ICGC	PTPPLE	DEG_SCF_FBW7_2	0.1667
p.E49D	DO222884	COCA	ICGC	PTPPLE	DEG_SCF_FBW7_2	0.25
p.T42P	SIDM00377	Other Sarcomas	GDSC	PTPPLE	DEG_SCF_FBW7_2	0.7031
p.T42P	SKN	soft_tissue	COSMIC	PTPPLE	DEG_SCF_FBW7_2	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13316	Dentin matrix acidic phosphoprotein 1	DEG_SCF_FBW7_2	41:46	PTPPLE	FBXW7	0.9202	More...
Q8TER5	Rho guanine nucleotide exchange factor 40	DEG_SCF_FBW7_2	496:501	PTPPLE	FBXW7	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons