DegronMD - Q13316(DMP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G110R	TCGA-21-1079	LUSC	TCGA	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.7568
p.G110R	DO26846	LUSC	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.7568
p.G115D	TCGA-BR-4363	STAD	TCGA	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2778
p.G115D	DO38815	STAD	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2778
p.D103Y	TCGA-CA-6717	COAD	TCGA	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.1944
p.D103Y	DO8264	COAD	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.1944
p.D104N	TCGA-CN-5360	HNSC	TCGA	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2222
p.D104N	DO14662	HNSC	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2222
p.D112E	TCGA-CV-6940	HNSC	TCGA	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.5647
p.D112E	DO15903	HNSC	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.5647
p.E31K	TCGA-DA-A95Y	SKCM	TCGA	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.0556
p.E31K	DO23398	LINC	ICGC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.0556
p.E31K	DO223908	SKCM	ICGC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.0556
p.E31K	SIDM00505	Pancreatic Carcinoma	GDSC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.0556
p.E31K	MIA-PaCa-2	pancreas	COSMIC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.0556
p.G115C	TCGA-EB-A24C	SKCM	TCGA	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2778
p.G115C	DO37438	SKCM	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2778
p.K55N	TCGA-FF-8042	DLBC	TCGA	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation substituting flanking lysine	0.1944
p.K55N	DO222306	DLBC	ICGC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation substituting flanking lysine	0.1944
p.G35D	TCGA-FR-A726	SKCM	TCGA	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.1667
p.G35D	DO48665	SKCM	ICGC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.1667
p.E106K	DO222617	BTCA	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2778
p.E49D	DO222884	COCA	ICGC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation rewiring degron network	0.25
p.D112H	DO234150	ESAD	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.6577
p.D118Y	DO228976	LICA	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.1944
p.D100Y	DO229027	LICA	ICGC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.1111
p.T113S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.6005
p.T113S	ACH-000656	Lymphoma	CCLE	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.6005
p.T113S	SU-DHL-8	NS	COSMIC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation altering degron motif	0.6005
p.G98E	SIDM00545	Melanoma	GDSC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.0556
p.G98E	ACH-000987	Skin Cancer	CCLE	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.0556
p.G98E	Mewo	skin	COSMIC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.0556
p.T42P	SIDM00377	Other Sarcomas	GDSC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation altering degron motif	0.7031
p.T42P	SKN	soft tissue	COSMIC	PTPPLE	DEG_SCF_FBW7_2	41:46	Mutation altering degron motif	0.7031
p.D105N	SIDM00193	Colorectal Carcinoma	GDSC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.25
p.D105N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.25
p.D105N	SNU-81	large intestine	COSMIC	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.25
p.D117H	ACH-001570	Skin Cancer	CCLE	DSGDDT	DEG_SCF_TRCP1_1	108:113	Mutation rewiring degron network	0.2222

Kaplan plot for DMP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DMP1

UniProt ID: Q13316

Entrez ID: 1758

Protein name: Dentin matrix acidic phosphoprotein 1 (DMP-1) (Dentin matrix protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DMP1 in