DegronMD

Uniprot ID: Q13316

Source protein: Dentin matrix acidic phosphoprotein 1

Source gene: DMP1

Class: DEG_SCF_TRCP1_1

Location: 108:113

E3 ligase: BTRC

DEGRON score: 0.9795

ASA_SCORE: 90.0333

COIL: 0.9572

CONS_SCORE: 0.9647

DSS_SCORE: 0.8317

HELIX: 0.0323

FCONS_SCORE: 1.3478

RIG_SCORE: 0.6022

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G110R	TCGA-21-1079	LUSC	TCGA	DSGDDT	DEG_SCF_TRCP1_1	0.7568
p.G110R	DO26846	LUSC	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.7568
p.G115D	TCGA-BR-4363	STAD	TCGA	DSGDDT	DEG_SCF_TRCP1_1	0.2778
p.G115D	DO38815	STAD	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.2778
p.D103Y	TCGA-CA-6717	COAD	TCGA	DSGDDT	DEG_SCF_TRCP1_1	0.1944
p.D103Y	DO8264	COAD	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.1944
p.D104N	TCGA-CN-5360	HNSC	TCGA	DSGDDT	DEG_SCF_TRCP1_1	0.2222
p.D104N	DO14662	HNSC	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.2222
p.D112E	TCGA-CV-6940	HNSC	TCGA	DSGDDT	DEG_SCF_TRCP1_1	0.5647
p.D112E	DO15903	HNSC	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.5647
p.G115C	TCGA-EB-A24C	SKCM	TCGA	DSGDDT	DEG_SCF_TRCP1_1	0.2778
p.G115C	DO37438	SKCM	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.2778
p.E106K	DO222617	BTCA	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.2778
p.D112H	DO234150	ESAD	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.6577
p.D118Y	DO228976	LICA	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.1944
p.D100Y	DO229027	LICA	ICGC	DSGDDT	DEG_SCF_TRCP1_1	0.1111
p.T113S	SIDM00423	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSGDDT	DEG_SCF_TRCP1_1	0.6005
p.T113S	ACH-000656	Lymphoma	CCLE	DSGDDT	DEG_SCF_TRCP1_1	0.6005
p.T113S	SU-DHL-8	NS	COSMIC	DSGDDT	DEG_SCF_TRCP1_1	0.6005
p.G98E	SIDM00545	Melanoma	GDSC	DSGDDT	DEG_SCF_TRCP1_1	0.0556
p.G98E	ACH-000987	Skin Cancer	CCLE	DSGDDT	DEG_SCF_TRCP1_1	0.0556
p.G98E	Mewo	skin	COSMIC	DSGDDT	DEG_SCF_TRCP1_1	0.0556
p.D105N	SIDM00193	Colorectal Carcinoma	GDSC	DSGDDT	DEG_SCF_TRCP1_1	0.25
p.D105N	ACH-000991	Colon/Colorectal Cancer	CCLE	DSGDDT	DEG_SCF_TRCP1_1	0.25
p.D105N	SNU-81	large_intestine	COSMIC	DSGDDT	DEG_SCF_TRCP1_1	0.25
p.D117H	ACH-001570	Skin Cancer	CCLE	DSGDDT	DEG_SCF_TRCP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q13316	Dentin matrix acidic phosphoprotein 1	DEG_SCF_TRCP1_1	108:113	DSGDDT	BTRC	0.9795	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons