DegronMD

Uniprot ID: Q8TER5

Source protein: Rho guanine nucleotide exchange factor 40

Source gene: ARHGEF40

Class: DEG_SCF_FBW7_2

Location: 1072:1078

E3 ligase: FBXW7

DEGRON score: 0.6717

ASA_SCORE: 80.8143

COIL: 0.6229

CONS_SCORE: 0.2776

DSS_SCORE: 0.5632

HELIX: 0.3411

FCONS_SCORE: 0.7592

RIG_SCORE: 0.725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1062Q	TCGA-D1-A2G0	UCEC	TCGA	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062Q	DO43049	UCEC	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062Q	SIDM00281	Other Solid Cancers	GDSC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062Q	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062Q	SIDM01526	Mesothelioma	GDSC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062Q	JEKO-1	haematopoietic_and_lymphoid_tissue	COSMIC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062Q	DJM-1	skin	COSMIC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1079H	TCGA-D5-6530	COAD	TCGA	VGTPRME	DEG_SCF_FBW7_2	0.3056
p.R1079H	DO8312	COAD	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.3056
p.R1079H	SIDM01460	Glioma	GDSC	VGTPRME	DEG_SCF_FBW7_2	0.3056
p.R1079H	ACH-000592	Brain Cancer	CCLE	VGTPRME	DEG_SCF_FBW7_2	0.3056
p.G1073C	TCGA-DI-A1BU	UCEC	TCGA	VGTPRME	DEG_SCF_FBW7_2	0.6489
p.G1073C	DO42023	UCEC	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.6489
p.R1062L	TCGA-GS-A9TT	DLBC	TCGA	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062L	DO219912	DLBC	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.A1085S	DO228976	LICA	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.1389
p.A1063D	DO49199	PACA	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.0833
p.R1079C	DO232224	PBCA	ICGC	VGTPRME	DEG_SCF_FBW7_2	0.3056
p.R1062W	SIDM01051	Ovarian Carcinoma	GDSC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062W	ACH-000936	Ovarian Cancer	CCLE	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1062W	EFO-27	ovary	COSMIC	VGTPRME	DEG_SCF_FBW7_2	0.0556
p.R1081Q	ACH-000824	Esophageal Cancer	CCLE	VGTPRME	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TER5	Rho guanine nucleotide exchange factor 40	DEG_SCF_FBW7_2	1072:1078	VGTPRME	FBXW7	0.6717	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons