DegronMD - O94875(SORBS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E581G	TCGA-A2-A1FZ	BRCA	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7199
p.E581G	DO2770	BRCA	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7199
p.E568K	TCGA-AA-3845	COAD	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0833
p.E568K	TCGA-CN-4740	HNSC	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0833
p.E568K	DO10020	COAD	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0833
p.E568K	DO14846	HNSC	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0833
p.R285Q	TCGA-B5-A3FA	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7329
p.H586P	TCGA-BQ-5890	KIRP	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.H586P	DO20766	KIRP	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.R285W	TCGA-BS-A0UV	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.8634
p.Y580C	TCGA-D8-A1Y0	BRCA	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7087
p.Y580C	DO3376	BRCA	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7087
p.P295S	TCGA-EE-A29T	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1667
p.S572F	TCGA-FW-A3R5	SKCM	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.S572F	DO37406	SKCM	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.V573M	TCGA-VQ-A8E7	STAD	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.V573M	DO222347	STAD	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.E288K	DO2401	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7022
p.D284H	DO2401	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.3056
p.R277H	DO8842	COAD	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5556
p.R277H	DO43041	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5556
p.R277H	DO42793	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5556
p.E294Q	DO48205	ESCA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6389
p.R292W	DO233853	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6944
p.R292W	DO41488	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6944
p.K290I	DO52050	HNSC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.3056
p.E294D	DO231683	LINC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6389
p.E298K	DO229177	LMS	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5278
p.I278L	DO45506	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5833
p.P281S	DO37742	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2222
p.N287K	DO40924	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.6918
p.R277C	DO43306	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5556
p.I278T	DO41887	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5833
p.F293L	DO41488	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation substituting flanking lysine	0.3333
p.P278L	SIDM02050	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5833
p.R281Q	SIDM00135	Breast Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2222
p.R281Q	Hs-578-T	breast	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2222
p.L589M	SIDM00437	Acute Myeloid Leukemia	GDSC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1389
p.L589M	SIDM00572	Gastric Carcinoma	GDSC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1389
p.L589M	SIDM01472	Hepatocellular Carcinoma	GDSC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1389
p.D281A	SIDM00845	Burkitt's Lymphoma	GDSC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.2222
p.A592V	SIDM00282	Colorectal Carcinoma	GDSC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0556
p.A592V	CW-2	large intestine	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0556
p.S295L	SIDM00516	Melanoma	GDSC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1667
p.S295L	ACH-002166	Skin Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1667
p.S295L	MZ7-mel	skin	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.1667
p.D284G	SIDM00217	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.3056
p.D284G	ACH-000999	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.3056
p.D284G	SNU-1040	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation rewiring degron network	0.3056
p.T299A	ACH-000959	Colon/Colorectal Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5
p.R286Q	GP5d	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7329
p.D287G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7198
p.A582T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7139
p.A591V	LNCaP-Clone-FGC	prostate	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0833
p.G586W	KYSE-410	oesophagus	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.G586W	YH-13	central nervous system	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.G586W	SNU-C5	large intestine	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2222
p.S288N	HLE	liver	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.818
p.T570A	NCI-H1048	lung	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1389
p.L590W	H2461	pleura	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1111
p.L585W	H2461	pleura	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.25
p.L568W	H2461	pleura	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.0833
p.T584K	RS4-11	haematopoietic and lymphoid tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.2778
p.G587R	NCC010	kidney	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1944
p.P589T	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation rewiring degron network	0.1389
p.R581G	K5	thyroid	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7568

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SORBS2

UniProt ID: O94875

Entrez ID: 8470

Protein name: Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SORBS2 in