DegronMD - O94875(SORBS2)

FUNCTION: Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1. May play a role in the regulation of pancreatic cell adhesion, pos... View more >>

GO - Biological processes (BP): actin filament organization [GO:0007015]; cell growth involved in cardiac muscle cell development [GO:0061049]; Notch signaling pathway [GO:0007219]

GO - Molecular function (MF): cytoskeletal anchor activity [GO:0008093]; identical protein binding [GO:0042802]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]

GO - Cellular component (CC): actin cytoskeleton [GO:0015629]; apical plasma membrane [GO:0016324]; dendrite [GO:0030425]; focal adhesion [GO:0005925]; lamellipodium [GO:0030027]; neuronal cell body [GO:0043025]; nucleus [GO:0005634]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; synapse [GO:0045202... View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R285W	TCGA-BS-A0UV	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.8634
p.S288N	HLE	liver	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.818
p.R581G	K5	thyroid	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7568
p.R285Q	TCGA-B5-A3FA	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7329
p.R286Q	GP5d	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7329
p.E581G	TCGA-A2-A1FZ	BRCA	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7199
p.E581G	DO2770	BRCA	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7199
p.D287G	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7198
p.A582T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7139
p.Y580C	TCGA-D8-A1Y0	BRCA	TCGA	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7087
p.Y580C	DO3376	BRCA	ICGC	VPIHIE	LIG_APCC_ABBA_1	577:582	Mutation altering degron motif	0.7087
p.E288K	DO2401	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.7022
p.R292W	DO233853	GACA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6944
p.R292W	DO41488	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6944
p.N287K	DO40924	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation altering degron motif	0.6918
p.E294Q	DO48205	ESCA	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6389
p.E294D	DO231683	LINC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.6389
p.I278L	DO45506	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5833
p.I278T	DO41887	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5833
p.P278L	SIDM02050	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	285:289	Mutation blocking phosphorylation signal	0.5833

Showing 1 to 20 of 66 entries

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Kaplan plot for SORBS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SORBS2

UniProt ID: O94875

Entrez ID: 8470

Protein name: Sorbin and SH3 domain-containing protein 2 (Arg-binding protein 2) (ArgBP2) (Arg/Abl-interacting protein 2) (Sorbin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SORBS2 in