DegronMD

Uniprot ID: O94875

Source protein: Sorbin and SH3 domain-containing protein 2

Source gene: SORBS2

Class: LIG_APCC_ABBA_1

Location: 577:582

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9818

ASA_SCORE: 82.7833

COIL: 0.7418

CONS_SCORE: 0.5372

DSS_SCORE: 0.5535

HELIX: 0.0315

FCONS_SCORE: 1.2739

RIG_SCORE: 0.7772

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E581G	TCGA-A2-A1FZ	BRCA	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.7199
p.E581G	DO2770	BRCA	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.7199
p.E568K	TCGA-AA-3845	COAD	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.0833
p.E568K	TCGA-CN-4740	HNSC	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.0833
p.E568K	DO10020	COAD	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.0833
p.E568K	DO14846	HNSC	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.0833
p.H586P	TCGA-BQ-5890	KIRP	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.H586P	DO20766	KIRP	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.Y580C	TCGA-D8-A1Y0	BRCA	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.7087
p.Y580C	DO3376	BRCA	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.7087
p.S572F	TCGA-FW-A3R5	SKCM	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.1944
p.S572F	DO37406	SKCM	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.1944
p.V573M	TCGA-VQ-A8E7	STAD	TCGA	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.V573M	DO222347	STAD	ICGC	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.L589M	SIDM00437	Acute Myeloid Leukemia	GDSC	VPIHIE	LIG_APCC_ABBA_1	0.1389
p.L589M	SIDM00572	Gastric Carcinoma	GDSC	VPIHIE	LIG_APCC_ABBA_1	0.1389
p.L589M	SIDM01472	Hepatocellular Carcinoma	GDSC	VPIHIE	LIG_APCC_ABBA_1	0.1389
p.A592V	SIDM00282	Colorectal Carcinoma	GDSC	VPIHIE	LIG_APCC_ABBA_1	0.0556
p.A592V	CW-2	large_intestine	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.0556
p.A582T	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.7139
p.A591V	LNCaP-Clone-FGC	prostate	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.0833
p.G586W	KYSE-410	oesophagus	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.G586W	YH-13	central_nervous_system	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.G586W	SNU-C5	large_intestine	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.2222
p.T570A	NCI-H1048	lung	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.1389
p.L590W	H2461	pleura	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.1111
p.L585W	H2461	pleura	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.25
p.L568W	H2461	pleura	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.0833
p.T584K	RS4-11	haematopoietic_and_lymphoid_tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.2778
p.G587R	NCC010	kidney	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.1944
p.P589T	SU-DHL-5	haematopoietic_and_lymphoid_tissue	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.1389
p.R581G	K5	thyroid	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94875	Sorbin and SH3 domain-containing protein 2	LIG_APCC_ABBA_1	577:582	VPIHIE	APC,CDC20,FZR1	0.9818	More...
Q5VZK9	F-actin-uncapping protein LRRC16A	LIG_APCC_ABBA_1	949:954	VPIHIE	APC,CDC20,FZR1	0.8287	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VPIHIE

Degron related mutations and impact score

Drug responses associated with SORBS2 mutations

All proteins holding degron of VPIHIE