DegronMD

Uniprot ID: Q5VZK9

Source protein: F-actin-uncapping protein LRRC16A

Source gene: CARMIL1

Class: LIG_APCC_ABBA_1

Location: 949:954

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8287

ASA_SCORE: 86.7

COIL: 0.8867

CONS_SCORE: 0.3486

DSS_SCORE: 0.4368

HELIX: 0.0488

FCONS_SCORE: 1.0585

RIG_SCORE: 0.7671

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E954K	HCC2998	large_intestine	COSMIC	VPIHIE	LIG_APCC_ABBA_1	0.7022

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94875	Sorbin and SH3 domain-containing protein 2	LIG_APCC_ABBA_1	577:582	VPIHIE	APC,CDC20,FZR1	0.9818	More...
Q5VZK9	F-actin-uncapping protein LRRC16A	LIG_APCC_ABBA_1	949:954	VPIHIE	APC,CDC20,FZR1	0.8287	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons