DegronMD - O15061(SYNM)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E966K	TCGA-2E-A9G8	UCEC	TCGA	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation altering degron motif	0.591
p.E956D	TCGA-AP-A059	UCEC	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.25
p.E956D	TCGA-AP-A059	UCEC	TCGA	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.1111
p.E956D	DO41361	UCEC	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.25
p.E956D	DO41361	UCEC	ICGC	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.1111
p.S1304N	TCGA-AX-A0J0	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7069
p.S1304N	DO41133	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7069
p.P960S	TCGA-BF-A3DM	SKCM	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.1389
p.P960S	TCGA-BF-A3DM	SKCM	TCGA	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.2222
p.P960L	TCGA-BF-A3DM	SKCM	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.1389
p.P960L	TCGA-BF-A3DM	SKCM	TCGA	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.2222
p.P960L	DO48667	SKCM	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.1389
p.P960L	DO48667	SKCM	ICGC	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.2222
p.P978Q	TCGA-BQ-7049	KIRP	TCGA	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.1667
p.P978L	TCGA-CV-7568	HNSC	TCGA	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.1667
p.T78P	TCGA-DD-AACE	LIHC	TCGA	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.T78P	DO52200	LIHC	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.E1298K	TCGA-DU-6392	LGG	TCGA	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.2222
p.E1298K	DO22237	LGG	ICGC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.2222
p.M936I	TCGA-L5-A88W	ESCA	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation blocking phosphorylation signal	0.5278
p.A87V	DO51918	BLCA	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.G979E	DO228123	EOPC	ICGC	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.1389
p.G953R	DO228732	GACA	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation altering degron motif	0.7568
p.N83S	DO51816	LGG	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1944
p.N83S	DO23460	LINC	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1944
p.V1295L	DO229031	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.1389
p.S81I	DO229035	LICA	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.1389
p.S945L	DO23891	LUAD	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation altering degron motif	0.7667
p.S945L	DO223907	SKCM	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation altering degron motif	0.7667
p.E960D	DO26647	LUSC	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.1389
p.E960D	DO26647	LUSC	ICGC	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.2222
p.Q99E	DO52686	MALY	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.25
p.T971S	DO33008	PACA	ICGC	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation altering degron motif	0.7116
p.G105R	DO37415	SKCM	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0833
p.D956Y	DO43186	UCEC	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation rewiring degron network	0.25
p.D956Y	DO43186	UCEC	ICGC	MREELSALT	DEG_APCC_DBOX_1	964:972	Mutation rewiring degron network	0.1111
p.R106C	SIDM01289	Esophageal Carcinoma	GDSC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.P1302L	SIDM00234	Other Solid Cancers	GDSC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	SIDM00491	Thyroid Gland Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	SIDM00587	Biliary Tract Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	SIDM00580	Acute Myeloid Leukemia	GDSC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	JEKO-1	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	ASH-3	thyroid	COSMIC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	HuCCT1	biliary tract	COSMIC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1302L	TC-YIK	cervix	COSMIC	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation altering degron motif	0.7582
p.P1301L	ACH-000168	Leukemia	CCLE	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.P1301L	ACH-000357	Lymphoma	CCLE	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.P1301L	ACH-000976	Bile Duct Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.P1301L	ACH-001443	Thyroid Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.P1301L	ACH-002201	Cervical Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	1302:1306	Mutation rewiring degron network	0.3056
p.H95Q	ACH-000794	Head and Neck Cancer	CCLE	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7582
p.H95Q	BICR22	upper aerodigestive tract	COSMIC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.7582
p.E947K	ACH-000805	Skin Cancer	CCLE	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation altering degron motif	0.7022
p.E947K	COLO-679	skin	COSMIC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation altering degron motif	0.7022
p.E94K	ACH-000980	Lung Cancer	CCLE	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.591
p.S945T	HSC-2	upper aerodigestive tract	COSMIC	PRQQLVEVI	DEG_APCC_DBOX_1	945:953	Mutation altering degron motif	0.7116
p.R96C	CTB-1	haematopoietic and lymphoid tissue	COSMIC	LRRELRELQ	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYNM

UniProt ID: O15061

Entrez ID: 23336

Protein name: Synemin (Desmuslin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYNM in