DegronMD

Uniprot ID: O15061

Source protein: Synemin

Source gene: SYNM

Class: DEG_APCC_DBOX_1

Location: 964:972

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9918

ASA_SCORE: 68.2889

COIL: 0.2993

CONS_SCORE: 0.6517

DSS_SCORE: 0.6249

HELIX: 0.675

FCONS_SCORE: 1.2162

RIG_SCORE: 0.7699

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E966K	TCGA-2E-A9G8	UCEC	TCGA	MREELSALT	DEG_APCC_DBOX_1	0.591
p.E956D	TCGA-AP-A059	UCEC	TCGA	MREELSALT	DEG_APCC_DBOX_1	0.1111
p.E956D	DO41361	UCEC	ICGC	MREELSALT	DEG_APCC_DBOX_1	0.1111
p.P960S	TCGA-BF-A3DM	SKCM	TCGA	MREELSALT	DEG_APCC_DBOX_1	0.2222
p.P960L	TCGA-BF-A3DM	SKCM	TCGA	MREELSALT	DEG_APCC_DBOX_1	0.2222
p.P960L	DO48667	SKCM	ICGC	MREELSALT	DEG_APCC_DBOX_1	0.2222
p.P978Q	TCGA-BQ-7049	KIRP	TCGA	MREELSALT	DEG_APCC_DBOX_1	0.1667
p.P978L	TCGA-CV-7568	HNSC	TCGA	MREELSALT	DEG_APCC_DBOX_1	0.1667
p.G979E	DO228123	EOPC	ICGC	MREELSALT	DEG_APCC_DBOX_1	0.1389
p.E960D	DO26647	LUSC	ICGC	MREELSALT	DEG_APCC_DBOX_1	0.2222
p.T971S	DO33008	PACA	ICGC	MREELSALT	DEG_APCC_DBOX_1	0.7116
p.D956Y	DO43186	UCEC	ICGC	MREELSALT	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15061	Synemin	DEG_APCC_DBOX_1	964:972	MREELSALT	APC,CDC20,FZR1	0.9918	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons