DegronMD

Uniprot ID: O15061

Source protein: Synemin

Source gene: SYNM

Class: DEG_APCC_DBOX_1

Location: 945:953

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9836

ASA_SCORE: 67.2111

COIL: 0.3591

CONS_SCORE: 0.6161

DSS_SCORE: 0.5048

HELIX: 0.6146

FCONS_SCORE: 1.1777

RIG_SCORE: 0.7683

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E956D	TCGA-AP-A059	UCEC	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	0.25
p.E956D	DO41361	UCEC	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.25
p.P960S	TCGA-BF-A3DM	SKCM	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	0.1389
p.P960L	TCGA-BF-A3DM	SKCM	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	0.1389
p.P960L	DO48667	SKCM	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.1389
p.M936I	TCGA-L5-A88W	ESCA	TCGA	PRQQLVEVI	DEG_APCC_DBOX_1	0.5278
p.G953R	DO228732	GACA	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.7568
p.S945L	DO23891	LUAD	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.7667
p.S945L	DO223907	SKCM	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.7667
p.E960D	DO26647	LUSC	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.1389
p.D956Y	DO43186	UCEC	ICGC	PRQQLVEVI	DEG_APCC_DBOX_1	0.25
p.E947K	ACH-000805	Skin Cancer	CCLE	PRQQLVEVI	DEG_APCC_DBOX_1	0.7022
p.E947K	COLO-679	skin	COSMIC	PRQQLVEVI	DEG_APCC_DBOX_1	0.7022
p.S945T	HSC-2	upper_aerodigestive_tract	COSMIC	PRQQLVEVI	DEG_APCC_DBOX_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15061	Synemin	DEG_APCC_DBOX_1	945:953	PRQQLVEVI	APC,CDC20,FZR1	0.9836	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons