DegronMD

Uniprot ID: O15061

Source protein: Synemin

Source gene: SYNM

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5551

ASA_SCORE: 78.5444

COIL: 0.0062

CONS_SCORE: 0.6674

DSS_SCORE: 0.3246

HELIX: 0.9938

FCONS_SCORE: 1.1615

RIG_SCORE: 0.7965

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T78P	TCGA-DD-AACE	LIHC	TCGA	LRRELRELQ	DEG_APCC_DBOX_1	0.0556
p.T78P	DO52200	LIHC	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.0556
p.A87V	DO51918	BLCA	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.3056
p.N83S	DO51816	LGG	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.1944
p.N83S	DO23460	LINC	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.1944
p.S81I	DO229035	LICA	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.1389
p.Q99E	DO52686	MALY	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.25
p.G105R	DO37415	SKCM	ICGC	LRRELRELQ	DEG_APCC_DBOX_1	0.0833
p.R106C	SIDM01289	Esophageal Carcinoma	GDSC	LRRELRELQ	DEG_APCC_DBOX_1	0.0556
p.H95Q	ACH-000794	Head and Neck Cancer	CCLE	LRRELRELQ	DEG_APCC_DBOX_1	0.7582
p.H95Q	BICR22	upper_aerodigestive_tract	COSMIC	LRRELRELQ	DEG_APCC_DBOX_1	0.7582
p.E94K	ACH-000980	Lung Cancer	CCLE	LRRELRELQ	DEG_APCC_DBOX_1	0.591
p.R96C	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRRELRELQ	DEG_APCC_DBOX_1	0.8301

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15061	Synemin	DEG_APCC_DBOX_1	88:96	LRRELRELQ	APC,CDC20,FZR1	0.5551	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons