DegronMD - Q9NZB2(FAM120A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H338L	TCGA-55-7994	LUAD	TCGA	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.H338L	DO45311	LUAD	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.P445H	TCGA-AX-A3G9	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0833
p.P445H	DO41241	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0833
p.T407M	TCGA-C5-A1MN	CESC	TCGA	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.0833
p.T407M	TCGA-IB-7651	PAAD	TCGA	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.0833
p.T407M	DO6257	CESC	ICGC	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.0833
p.T407M	DO46657	PAAD	ICGC	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.0833
p.Y342C	TCGA-C5-A8ZZ	CESC	TCGA	PPHY	ITCH	339:342	Mutation altering degron motif	0.8198
p.Y342C	DO49912	CESC	ICGC	PPHY	ITCH	339:342	Mutation altering degron motif	0.8198
p.D465N	TCGA-D3-A3ML	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1389
p.D465N	DO47413	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1389
p.D463N	TCGA-EO-A22U	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1944
p.D463N	DO43755	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1944
p.K410N	TCGA-EO-A22X	UCEC	TCGA	NSYSNIP	CBL_PTK	416:422	Mutation substituting flanking lysine	0.2778
p.K410N	DO43907	UCEC	ICGC	NSYSNIP	CBL_PTK	416:422	Mutation substituting flanking lysine	0.2778
p.V448M	TCGA-EO-A3AV	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	DO52412	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	SIDM00487	Colorectal Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	SIDM00251	Gastric Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	SIDM00469	Pancreatic Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	CCK-81	large intestine	COSMIC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	TGBC11TKB	stomach	COSMIC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	PSN1	pancreas	COSMIC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.V448M	TE-8	oesophagus	COSMIC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1667
p.D449G	TCGA-EO-A3KX	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1944
p.D449G	DO219774	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.1944
p.H338Y	TCGA-EW-A1J5	BRCA	TCGA	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.H338Y	DO6144	BRCA	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.E424K	TCGA-F5-6814	READ	TCGA	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.2778
p.E424K	DO36556	READ	ICGC	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.2778
p.E424K	ACH-000991	Colon/Colorectal Cancer	CCLE	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.2778
p.E424K	SNU-81	large intestine	COSMIC	NSYSNIP	CBL_PTK	416:422	Mutation rewiring degron network	0.2778
p.S459L	DO225081	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.3056
p.S459L	DO52559	BRCA	ICGC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.3056
p.H338D	DO234272	ESAD	ICGC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.3056
p.P349L	SIDM02035	Colorectal Carcinoma	GDSC	PPHY	ITCH	339:342	Mutation rewiring degron network	0.1389
p.H341R	SIDM00458	Acute Myeloid Leukemia	GDSC	PPHY	ITCH	339:342	Mutation altering degron motif	0.7133
p.H341R	ACH-000751	Leukemia	CCLE	PPHY	ITCH	339:342	Mutation altering degron motif	0.7133
p.H341R	OCI-M1	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	339:342	Mutation altering degron motif	0.7133
p.S468R	SIDM00094	Kidney Carcinoma	GDSC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0556
p.S468R	ACH-002199	Kidney Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0556
p.S468R	SN12C	kidney	COSMIC	PGSST	DEG_SPOP_SBC_1	454:458	Mutation rewiring degron network	0.0556
p.S332T	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPHY	ITCH	339:342	Mutation rewiring degron network	0.1389
p.K333R	ACH-000961	Endometrial/Uterine Cancer	CCLE	PPHY	ITCH	339:342	Mutation substituting flanking lysine	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FAM120A

UniProt ID: Q9NZB2

Entrez ID: 23196

Protein name: Constitutive coactivator of PPAR-gamma-like protein 1 (Oxidative stress-associated Src activator) (Protein FAM120A)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FAM120A in