DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NSYSNIP
Uniprot ID:
Q9NZB2
Source protein:
Constitutive coactivator of PPAR-gamma-like protein 1
Source gene:
FAM120A
Class:
CBL_PTK
Location:
416:422
E3 ligase:
CBL
DEGRON score:
0.9992
ASA_SCORE:
69.0286
COIL:
0.7763
CONS_SCORE:
0.4341
DSS_SCORE:
0.6592
HELIX:
0.1376
FCONS_SCORE:
1.13
RIG_SCORE:
0.6396
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.T407M
TCGA-C5-A1MN
CESC
TCGA
NSYSNIP
CBL_PTK
0.0833
p.T407M
TCGA-IB-7651
PAAD
TCGA
NSYSNIP
CBL_PTK
0.0833
p.T407M
DO6257
CESC
ICGC
NSYSNIP
CBL_PTK
0.0833
p.T407M
DO46657
PAAD
ICGC
NSYSNIP
CBL_PTK
0.0833
p.K410N
TCGA-EO-A22X
UCEC
TCGA
NSYSNIP
CBL_PTK
0.2778
p.K410N
DO43907
UCEC
ICGC
NSYSNIP
CBL_PTK
0.2778
p.E424K
TCGA-F5-6814
READ
TCGA
NSYSNIP
CBL_PTK
0.2778
p.E424K
DO36556
READ
ICGC
NSYSNIP
CBL_PTK
0.2778
p.E424K
ACH-000991
Colon/Colorectal Cancer
CCLE
NSYSNIP
CBL_PTK
0.2778
p.E424K
SNU-81
large_intestine
COSMIC
NSYSNIP
CBL_PTK
0.2778
Drug responses associated with FAM120A mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSYSNIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NZB2
Constitutive coactivator of PPAR-gamma-like protein 1
CBL_PTK
416:422
NSYSNIP
CBL
0.9992
More...
Q5T035
Putative uncharacterized protein C9orf129
CBL_PTK
65:71
NSYSNIP
CBL
0.998
More...
