DegronMD - Q5T035(C9orf129)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D114Y	TCGA-06-5413	GBM	TCGA	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1389
p.D114Y	DO11711	GBM	ICGC	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.1389
p.E81V	TCGA-96-A4JK	LUSC	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.0556
p.E81V	DO45442	LUSC	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.0556
p.E73K	TCGA-AP-A0LG	UCEC	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2778
p.E73K	TCGA-EY-A1GI	UCEC	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2778
p.E73K	DO41823	UCEC	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2778
p.E73K	DO41211	UCEC	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2778
p.A100T	TCGA-BR-4201	STAD	TCGA	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.25
p.A100T	DO38707	STAD	ICGC	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.25
p.T56M	TCGA-BR-8368	STAD	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.0833
p.T56M	DO47981	STAD	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.0833
p.L61M	TCGA-BS-A0TA	UCEC	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2222
p.L61M	DO43298	UCEC	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2222
p.E63K	TCGA-D1-A103	UCEC	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2778
p.E63K	DO42312	UCEC	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.2778
p.H72Y	TCGA-EE-A29E	SKCM	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.3056
p.H72Y	DO37831	SKCM	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.3056
p.P71S	TCGA-EE-A29E	SKCM	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation altering degron motif	0.6752
p.P71S	DO37831	SKCM	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation altering degron motif	0.6752
p.G74E	TCGA-FR-A728	SKCM	TCGA	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.25
p.G74E	DO48550	SKCM	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.25
p.S117I	TCGA-SW-A7EA	STAD	TCGA	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0556
p.S117I	DO51749	STAD	ICGC	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.0556
p.T62M	DO233162	GACA	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.25
p.G58R	DO233854	GACA	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.1389
p.G58R	DO231078	LUSC	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation rewiring degron network	0.1389
p.Y67N	DO228202	LICA	ICGC	NSYSNIP	CBL_PTK	65:71	Mutation altering degron motif	0.817
p.P103S	DO229502	SKCA	ICGC	PGSST	DEG_SPOP_SBC_1	103:107	Mutation altering degron motif	0.6752
p.T77M	SIDM01619	Endometrial Carcinoma	GDSC	NSYSNIP	CBL_PTK	65:71	Mutation blocking phosphorylation signal	0.6111
p.S108L	ACH-000472	Head and Neck Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	103:107	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

C9orf129

UniProt ID: Q5T035

Entrez ID: 445577

Protein name: Putative uncharacterized protein C9orf129

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for C9orf129 in