DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
NSYSNIP
Uniprot ID:
Q5T035
Source protein:
Putative uncharacterized protein C9orf129
Source gene:
C9orf129
Class:
CBL_PTK
Location:
65:71
E3 ligase:
CBL
DEGRON score:
0.998
ASA_SCORE:
59.2857
COIL:
0.8263
CONS_SCORE:
0.9428
DSS_SCORE:
0.6437
HELIX:
0.0993
FCONS_SCORE:
1.0078
RIG_SCORE:
0.6437
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.E81V
TCGA-96-A4JK
LUSC
TCGA
NSYSNIP
CBL_PTK
0.0556
p.E81V
DO45442
LUSC
ICGC
NSYSNIP
CBL_PTK
0.0556
p.E73K
TCGA-AP-A0LG
UCEC
TCGA
NSYSNIP
CBL_PTK
0.2778
p.E73K
TCGA-EY-A1GI
UCEC
TCGA
NSYSNIP
CBL_PTK
0.2778
p.E73K
DO41823
UCEC
ICGC
NSYSNIP
CBL_PTK
0.2778
p.E73K
DO41211
UCEC
ICGC
NSYSNIP
CBL_PTK
0.2778
p.T56M
TCGA-BR-8368
STAD
TCGA
NSYSNIP
CBL_PTK
0.0833
p.T56M
DO47981
STAD
ICGC
NSYSNIP
CBL_PTK
0.0833
p.L61M
TCGA-BS-A0TA
UCEC
TCGA
NSYSNIP
CBL_PTK
0.2222
p.L61M
DO43298
UCEC
ICGC
NSYSNIP
CBL_PTK
0.2222
p.E63K
TCGA-D1-A103
UCEC
TCGA
NSYSNIP
CBL_PTK
0.2778
p.E63K
DO42312
UCEC
ICGC
NSYSNIP
CBL_PTK
0.2778
p.H72Y
TCGA-EE-A29E
SKCM
TCGA
NSYSNIP
CBL_PTK
0.3056
p.H72Y
DO37831
SKCM
ICGC
NSYSNIP
CBL_PTK
0.3056
p.P71S
TCGA-EE-A29E
SKCM
TCGA
NSYSNIP
CBL_PTK
0.6752
p.P71S
DO37831
SKCM
ICGC
NSYSNIP
CBL_PTK
0.6752
p.G74E
TCGA-FR-A728
SKCM
TCGA
NSYSNIP
CBL_PTK
0.25
p.G74E
DO48550
SKCM
ICGC
NSYSNIP
CBL_PTK
0.25
p.T62M
DO233162
GACA
ICGC
NSYSNIP
CBL_PTK
0.25
p.G58R
DO233854
GACA
ICGC
NSYSNIP
CBL_PTK
0.1389
p.G58R
DO231078
LUSC
ICGC
NSYSNIP
CBL_PTK
0.1389
p.Y67N
DO228202
LICA
ICGC
NSYSNIP
CBL_PTK
0.817
p.T77M
SIDM01619
Endometrial Carcinoma
GDSC
NSYSNIP
CBL_PTK
0.6111
Drug responses associated with C9orf129 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NSYSNIP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9NZB2
Constitutive coactivator of PPAR-gamma-like protein 1
CBL_PTK
416:422
NSYSNIP
CBL
0.9992
More...
Q5T035
Putative uncharacterized protein C9orf129
CBL_PTK
65:71
NSYSNIP
CBL
0.998
More...