DegronMD - P18146(EGR1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R320H	TCGA-10-0930	OV	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1111
p.R320H	DO32113	OV	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1111
p.R320H	SIDM01619	Endometrial Carcinoma	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1111
p.R320H	ACH-000984	Endometrial/Uterine Cancer	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1111
p.S457Y	TCGA-12-0778	GBM	TCGA	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.712
p.S457Y	DO11411	GBM	ICGC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation altering degron motif	0.712
p.G276S	TCGA-17-Z005	LUAD	TCGA	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.1111
p.S172F	TCGA-21-5782	LUSC	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7982
p.S172F	DO27120	LUSC	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation altering degron motif	0.7982
p.A294D	TCGA-27-2527	GBM	TCGA	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.A294D	DO12298	GBM	ICGC	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.T331M	TCGA-32-2615	GBM	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7423
p.T331M	TCGA-A5-A0G1	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7423
p.T331M	TCGA-A6-6780	COAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7423
p.T331M	DO10244	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7423
p.T331M	DO11172	GBM	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7423
p.T331M	DO42472	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7423
p.S480L	TCGA-39-5031	LUSC	TCGA	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.S480L	TCGA-FD-A43X	BLCA	TCGA	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.S480L	DO44067	BLCA	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.S480L	DO26526	LUSC	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7667
p.R322C	TCGA-AA-3663	COAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322C	TCGA-CG-4306	STAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322C	TCGA-VQ-A8PB	STAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322C	DO9346	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322C	DO8858	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322C	DO38567	STAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322C	DO51766	STAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R336C	TCGA-AJ-A3BH	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R336C	DO41638	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R336C	SIDM00799	Glioblastoma	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R336C	ACH-000558	Brain Cancer	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R336C	A172	central nervous system	COSMIC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.E335K	TCGA-AP-A0LM	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7022
p.E335K	TCGA-E6-A1LX	UCEC	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7022
p.E335K	DO8730	COAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7022
p.E335K	DO43306	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7022
p.E335K	DO41020	UCEC	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.7022
p.P175L	TCGA-AP-A1DK	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.P175L	DO42033	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.25
p.D198N	TCGA-AP-A1DV	UCEC	TCGA	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5821
p.D198N	DO230309	COCA	ICGC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5821
p.D198N	DO43186	UCEC	ICGC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5821
p.A205V	TCGA-AX-A2HC	UCEC	TCGA	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5825
p.A205V	DO41572	UCEC	ICGC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5825
p.A182T	TCGA-B0-5697	KIRC	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.A182T	TCGA-KK-A59V	PRAD	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.A182T	DO16115	KIRC	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.A182T	DO51346	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0556
p.G489D	TCGA-B5-A3FA	UCEC	TCGA	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.G489D	DO52402	UCEC	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.1111
p.S173L	TCGA-B5-A5OC	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.3056
p.S173L	DO52405	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.3056
p.S460Y	TCGA-BL-A5ZZ	BLCA	TCGA	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.25
p.S460Y	TCGA-BL-A5ZZ	BLCA	TCGA	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.3056
p.S460Y	DO44027	BLCA	ICGC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.25
p.S460Y	DO44027	BLCA	ICGC	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.3056
p.P207S	TCGA-BR-8078	STAD	TCGA	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.6752
p.P207S	DO38288	STAD	ICGC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.6752
p.P201H	TCGA-CG-4305	STAD	TCGA	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.6583
p.P201H	DO38823	STAD	ICGC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.6583
p.S159N	TCGA-CK-4951	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0833
p.S159N	DO10582	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.0833
p.A174T	TCGA-CK-4951	COAD	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.A174T	DO10582	COAD	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.R280H	TCGA-D1-A167	UCEC	TCGA	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.R280H	TCGA-XF-A8HG	BLCA	TCGA	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.R280H	DO49802	BLCA	ICGC	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.R280H	DO40978	UCEC	ICGC	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.2222
p.Q248H	TCGA-DF-A2KN	UCEC	TCGA	PPAY	ITCH	237:240	Mutation rewiring degron network	0.1111
p.Q248H	DO223282	UCEC	ICGC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.1111
p.A294V	TCGA-DU-6392	LGG	TCGA	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.A294V	DO22237	LGG	ICGC	PSLTPLST	DEG_SCF_FBW7_1	284:291	Mutation rewiring degron network	0.25
p.P167A	TCGA-EJ-A8FS	PRAD	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.3056
p.P167A	DO51333	PRAD	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.3056
p.A193T	TCGA-EO-A22R	UCEC	TCGA	NDSSPIYSAAP	CBL_PTK	197:207	Mutation rewiring degron network	0.2222
p.A193T	DO42713	UCEC	ICGC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation rewiring degron network	0.2222
p.N166Y	TCGA-EY-A215	UCEC	TCGA	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.N166Y	DO42665	UCEC	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.2778
p.R327Q	TCGA-HQ-A2OF	BLCA	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R327Q	DO51898	BLCA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R327Q	SIDM00217	Colorectal Carcinoma	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.R327Q	ACH-000999	Colon/Colorectal Cancer	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.A242T	TCGA-HU-A4GN	STAD	TCGA	PPAY	ITCH	237:240	Mutation rewiring degron network	0.2778
p.A242T	DO47833	STAD	ICGC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.2778
p.A339T	TCGA-XK-AAIW	PRAD	TCGA	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.2222
p.A339T	DO51407	PRAD	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.2222
p.P477L	TCGA-YD-A9TA	SKCM	TCGA	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7582
p.P477L	DO219503	SKCM	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.7582
p.R322H	DO229389	BTCA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.R322H	DO233737	GACA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.1667
p.A232V	DO230326	COCA	ICGC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.1944
p.F490S	DO234401	ESAD	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.0833
p.A179S	DO233878	GACA	ICGC	PASSS	DEG_SPOP_SBC_1	168:172	Mutation rewiring degron network	0.1389
p.K244N	DO228952	LICA	ICGC	PPAY	ITCH	237:240	Mutation substituting flanking lysine	0.3333
p.P477S	DO229050	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation altering degron motif	0.6752
p.P483L	DO229050	LICA	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2778
p.R336L	DO229009	LICA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.3056
p.P333R	DO50847	LICA	ICGC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation altering degron motif	0.6401
p.S452F	DO222595	MELA	ICGC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.3056
p.S452F	DO222595	MELA	ICGC	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0833
p.P236S	DO222731	MELA	ICGC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.3056
p.P236S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.3056
p.P236S	ACH-000981	Leukemia	CCLE	PPAY	ITCH	237:240	Mutation rewiring degron network	0.3056
p.P236S	DND-41	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.3056
p.P485S	DO218912	SKCA	ICGC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.2222
p.P188L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation rewiring degron network	0.0833
p.P188L	ACH-000981	Leukemia	CCLE	NDSSPIYSAAP	CBL_PTK	197:207	Mutation rewiring degron network	0.0833
p.P188L	DND-41	haematopoietic and lymphoid tissue	COSMIC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation rewiring degron network	0.0833
p.P451S	SIDM00789	Colorectal Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.P451S	SIDM00789	Colorectal Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0556
p.P451S	ACH-000997	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.P451S	ACH-000997	Colon/Colorectal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0556
p.P451S	ACH-001061	Colon/Colorectal Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.P451S	ACH-001061	Colon/Colorectal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0556
p.P451S	HCT-15	large intestine	COSMIC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.2778
p.P451S	HCT-15	large intestine	COSMIC	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0556
p.P238L	SIDM00633	Breast Carcinoma	GDSC	PPAY	ITCH	237:240	Mutation altering degron motif	0.7582
p.P238L	ACH-000759	Breast Cancer	CCLE	PPAY	ITCH	237:240	Mutation altering degron motif	0.7582
p.P238L	MDA-MB-175-VII	breast	COSMIC	PPAY	ITCH	237:240	Mutation altering degron motif	0.7582
p.A232T	SIDM01007	T-Lymphoblastic Leukemia	GDSC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.1944
p.A232T	ACH-002256	Leukemia	CCLE	PPAY	ITCH	237:240	Mutation rewiring degron network	0.1944
p.A232T	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	PPAY	ITCH	237:240	Mutation rewiring degron network	0.1944
p.A447T	SIDM00704	Small Cell Lung Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1667
p.A447T	ACH-000639	Lung Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1667
p.A447T	NCI-H211	lung	COSMIC	PVTTS	DEG_SPOP_SBC_1	453:457	Mutation rewiring degron network	0.1667
p.P201S	SIDM00537	Colorectal Carcinoma	GDSC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5641
p.P201S	ACH-000982	Colon/Colorectal Cancer	CCLE	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5641
p.P201S	ACH-001345	Colon/Colorectal Cancer	CCLE	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5641
p.P201S	GP5d	large intestine	COSMIC	NDSSPIYSAAP	CBL_PTK	197:207	Mutation altering degron motif	0.5641
p.A339G	SIDM00145	T-Lymphoblastic Leukemia	GDSC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.2222
p.A339G	ACH-001127	Leukemia	CCLE	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.2222
p.A339G	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	PSKTPPHE	DEG_SCF_FBW7_2	328:335	Mutation rewiring degron network	0.2222
p.F474S	ACH-000639	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0833
p.F474S	ACH-000639	Lung Cancer	CCLE	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.F474S	NCI-H211	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	461:465	Mutation rewiring degron network	0.0833
p.F474S	NCI-H211	lung	COSMIC	PGSST	DEG_SPOP_SBC_1	477:481	Mutation rewiring degron network	0.25
p.Y240S	ACH-000971	Colon/Colorectal Cancer	CCLE	PPAY	ITCH	237:240	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EGR1

UniProt ID: P18146

Entrez ID: 1958

Protein name: Early growth response protein 1 (EGR-1) (AT225) (Nerve growth factor-induced protein A) (NGFI-A) (Transcription factor ETR103) (Transcription factor Zif268) (Zinc finger protein 225) (Zinc finger protein Krox-24)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EGR1 in