DegronMD

Uniprot ID: P18146

Source protein: Early growth response protein 1

Source gene: EGR1

Class: CBL_PTK

Location: 197:207

E3 ligase: CBL

DEGRON score: 0.9491

ASA_SCORE: 81.6364

COIL: 0.8955

CONS_SCORE: 0.4261

DSS_SCORE: 0.5302

HELIX: 0.0359

FCONS_SCORE: 0.9487

RIG_SCORE: 0.6239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D198N	TCGA-AP-A1DV	UCEC	TCGA	NDSSPIYSAAP	CBL_PTK	0.5821
p.D198N	DO230309	COCA	ICGC	NDSSPIYSAAP	CBL_PTK	0.5821
p.D198N	DO43186	UCEC	ICGC	NDSSPIYSAAP	CBL_PTK	0.5821
p.A205V	TCGA-AX-A2HC	UCEC	TCGA	NDSSPIYSAAP	CBL_PTK	0.5825
p.A205V	DO41572	UCEC	ICGC	NDSSPIYSAAP	CBL_PTK	0.5825
p.P207S	TCGA-BR-8078	STAD	TCGA	NDSSPIYSAAP	CBL_PTK	0.6752
p.P207S	DO38288	STAD	ICGC	NDSSPIYSAAP	CBL_PTK	0.6752
p.P201H	TCGA-CG-4305	STAD	TCGA	NDSSPIYSAAP	CBL_PTK	0.6583
p.P201H	DO38823	STAD	ICGC	NDSSPIYSAAP	CBL_PTK	0.6583
p.A193T	TCGA-EO-A22R	UCEC	TCGA	NDSSPIYSAAP	CBL_PTK	0.2222
p.A193T	DO42713	UCEC	ICGC	NDSSPIYSAAP	CBL_PTK	0.2222
p.P188L	SIDM00946	T-Lymphoblastic Leukemia	GDSC	NDSSPIYSAAP	CBL_PTK	0.0833
p.P188L	ACH-000981	Leukemia	CCLE	NDSSPIYSAAP	CBL_PTK	0.0833
p.P188L	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	NDSSPIYSAAP	CBL_PTK	0.0833
p.P201S	SIDM00537	Colorectal Carcinoma	GDSC	NDSSPIYSAAP	CBL_PTK	0.5641
p.P201S	ACH-000982	Colon/Colorectal Cancer	CCLE	NDSSPIYSAAP	CBL_PTK	0.5641
p.P201S	ACH-001345	Colon/Colorectal Cancer	CCLE	NDSSPIYSAAP	CBL_PTK	0.5641
p.P201S	GP5d	large_intestine	COSMIC	NDSSPIYSAAP	CBL_PTK	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P18146	Early growth response protein 1	CBL_PTK	197:207	NDSSPIYSAAP	CBL	0.9491	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons