DegronMD

Uniprot ID: P18146

Source protein: Early growth response protein 1

Source gene: EGR1

Class: DEG_SPOP_SBC_1

Location: 461:465

E3 ligase: SPOP

DEGRON score: 0.9422

ASA_SCORE: 81.28

COIL: 0.911

CONS_SCORE: 0.1995

DSS_SCORE: 0.4409

HELIX: 0.0494

FCONS_SCORE: 0.936

RIG_SCORE: 0.6215

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S460Y	TCGA-BL-A5ZZ	BLCA	TCGA	PATTS	DEG_SPOP_SBC_1	0.3056
p.S460Y	DO44027	BLCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.3056
p.S452F	DO222595	MELA	ICGC	PATTS	DEG_SPOP_SBC_1	0.0833
p.P451S	SIDM00789	Colorectal Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.0556
p.P451S	ACH-000997	Colon/Colorectal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.0556
p.P451S	ACH-001061	Colon/Colorectal Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.0556
p.P451S	HCT-15	large_intestine	COSMIC	PATTS	DEG_SPOP_SBC_1	0.0556
p.F474S	ACH-000639	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.0833
p.F474S	NCI-H211	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SPOP_SBC_1	652:656	PATTS	SPOP	0.8499	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	460:464	PATTS	SPOP	0.9973	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	461:465	PATTS	SPOP	0.9422	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	111:115	PATTS	SPOP	0.9679	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	151:155	PATTS	SPOP	0.9788	More...
Q00535	Cyclin-dependent kinase 5	DEG_SPOP_SBC_1	243:247	PATTS	SPOP	0.9123	More...
Q12815	Tastin	DEG_SPOP_SBC_1	667:671	PATTS	SPOP	0.6469	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	523:527	PATTS	SPOP	0.9934	More...
Q2UY09	Collagen alpha-1	DEG_SPOP_SBC_1	1045:1049	PATTS	SPOP	0.9604	More...
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_SPOP_SBC_1	433:437	PATTS	SPOP	0.9972	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7103:7107	PATTS	SPOP	0.9088	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7978:7982	PATTS	SPOP	0.8819	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8273:8277	PATTS	SPOP	0.9418	More...
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	DEG_SPOP_SBC_1	169:173	PATTS	SPOP	0.9946	More...
Q99816	Tumor susceptibility gene 101 protein	DEG_SPOP_SBC_1	197:201	PATTS	SPOP	0.9804	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	98:102	PATTS	SPOP	0.8588	More...
Q9Y6R0	Numb-like protein	DEG_SPOP_SBC_1	266:270	PATTS	SPOP	0.9987	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1751:1755	PATTS	SPOP	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons