DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 8273:8277

E3 ligase: SPOP

DEGRON score: 0.9418

ASA_SCORE: 86.34

COIL: 0.9132

CONS_SCORE: 0

DSS_SCORE: 0.4207

HELIX: 0.0108

FCONS_SCORE: 0

RIG_SCORE: 0.6194

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S8282F	TCGA-EE-A29D	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	TCGA-FS-A1ZP	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	TCGA-GN-A266	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	TCGA-WE-A8ZN	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	DO220857	MELA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	DO37703	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	DO37432	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	DO51285	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	DO38123	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	SIDM00860	Head and Neck Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	ACH-000846	Head and Neck Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	ACH-000953	Leukemia	CCLE	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8282F	FADU	upper_aerodigestive_tract	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8279F	TCGA-W3-AA1O	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.2778
p.S8279F	DO51274	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.2778
p.P8280L	TCGA-YD-A9TA	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.25
p.P8280L	DO219503	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.25
p.A8266D	DO229026	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.T8276I	DO50970	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.7078
p.P8278S	DO23204	LINC	ICGC	PATTS	DEG_SPOP_SBC_1	0.3056
p.S8267F	DO232051	ORCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1667
p.S8265P	SIDM02076	Esophageal Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.1111
p.P8280S	SIDM00007	Other Solid Cancers	GDSC	PATTS	DEG_SPOP_SBC_1	0.25
p.P8280S	ACH-001550	Skin Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.25
p.P8280S	MCC13	skin	COSMIC	PATTS	DEG_SPOP_SBC_1	0.25
p.S8268F	SIDM00007	Other Solid Cancers	GDSC	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8268F	ACH-001550	Skin Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1944
p.S8268F	MCC13	skin	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T8275M	SIDM00654	Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00210	Ovarian Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM01112	Osteosarcoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00650	Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00854	Burkitt's Lymphoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00849	Kidney Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00863	Burkitt's Lymphoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM01681	Non-Cancerous	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00673	Breast Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM00760	Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.T8275M	SIDM01318	Hepatocellular Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.7423
p.S8271Y	SIDM00223	Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.2778
p.S8271Y	ACH-002144	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.2778
p.S8271Y	IST-SL1	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	0.2778
p.T8284I	SIDM00653	Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.1389
p.T8284I	ACH-000514	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1389
p.T8284I	NCI-H1092	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1389
p.S8283F	SIDM00528	Breast Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.1667
p.S8283F	ACH-000934	Breast Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1667
p.S8283F	MDA-MB-361	breast	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SPOP_SBC_1	652:656	PATTS	SPOP	0.8499	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	460:464	PATTS	SPOP	0.9973	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	461:465	PATTS	SPOP	0.9422	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	111:115	PATTS	SPOP	0.9679	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	151:155	PATTS	SPOP	0.9788	More...
Q00535	Cyclin-dependent kinase 5	DEG_SPOP_SBC_1	243:247	PATTS	SPOP	0.9123	More...
Q12815	Tastin	DEG_SPOP_SBC_1	667:671	PATTS	SPOP	0.6469	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	523:527	PATTS	SPOP	0.9934	More...
Q2UY09	Collagen alpha-1	DEG_SPOP_SBC_1	1045:1049	PATTS	SPOP	0.9604	More...
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_SPOP_SBC_1	433:437	PATTS	SPOP	0.9972	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7103:7107	PATTS	SPOP	0.9088	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7978:7982	PATTS	SPOP	0.8819	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8273:8277	PATTS	SPOP	0.9418	More...
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	DEG_SPOP_SBC_1	169:173	PATTS	SPOP	0.9946	More...
Q99816	Tumor susceptibility gene 101 protein	DEG_SPOP_SBC_1	197:201	PATTS	SPOP	0.9804	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	98:102	PATTS	SPOP	0.8588	More...
Q9Y6R0	Numb-like protein	DEG_SPOP_SBC_1	266:270	PATTS	SPOP	0.9987	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1751:1755	PATTS	SPOP	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PATTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PATTS