DegronMD - O00562(PITPNM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P1221A	TCGA-35-4122	LUAD	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.7503
p.E1219K	TCGA-94-7943	LUSC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.2778
p.Q645E	TCGA-A2-A0YK	BRCA	TCGA	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1389
p.Q645E	DO2836	BRCA	ICGC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1389
p.A1216V	TCGA-A6-5661	COAD	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1944
p.R1230W	TCGA-AM-5821	COAD	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.25
p.R1234W	TCGA-B5-A3FC	UCEC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1389
p.S657F	TCGA-D3-A2JH	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.3056
p.S657F	DO47263	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.3056
p.R1218C	TCGA-DX-A7EQ	SARC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.25
p.E642K	TCGA-EO-A3KX	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0556
p.E642K	DO219774	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0556
p.R662Q	TCGA-F4-6856	COAD	TCGA	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1667
p.R662Q	DO9114	COAD	ICGC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1667
p.R662W	TCGA-F7-A624	HNSC	TCGA	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1667
p.R662W	DO44440	HNSC	ICGC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1667
p.R1234L	TCGA-PG-A6IB	UCEC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1389
p.A1215V	DO8634	COAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1667
p.R1229W	DO8240	COAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.2778
p.R1217H	DO223050	ESCA	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.2222
p.R1217H	DO233711	GACA	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.2222
p.T797N	DO229032	LICA	ICGC	VPSTPTST	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.7055
p.L807S	DO25444	LUAD	ICGC	VPSTPTST	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.0833
p.P1220A	DO23782	LUAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.3056
p.E1218K	DO26475	LUSC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.25
p.R1217C	DO220032	SARC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.2222
p.S1213G	DO38376	STAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1111
p.V790A	DO229211	THCA	ICGC	VPSTPTST	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.3056
p.L786M	DO229245	THCA	ICGC	VPSTPTST	DEG_SCF_FBW7_1	791:798	Mutation rewiring degron network	0.1944
p.R1233L	DO52419	UCEC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1667
p.R1233W	DO41871	UCEC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation rewiring degron network	0.1667
p.E642D	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0556
p.E642D	ACH-000432	Leukemia	CCLE	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0556
p.E642D	BV-173	haematopoietic and lymphoid tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0556
p.P1221L	SIDM00831	Head and Neck Carcinoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM00206	Glioblastoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM01047	Chronic Myelogenous Leukemia	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM00095	Glioblastoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM00516	Melanoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM00176	Chondrosarcoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM00059	Ovarian Carcinoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.P1221L	SIDM01879	Non-Cancerous	GDSC	PGTPPTT	DEG_SCF_FBW7_1	1221:1227	Mutation altering degron motif	0.6471
p.Q645R	SIDM00205	Ewing's Sarcoma	GDSC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1389
p.Q645R	ACH-002110	Bone Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1389
p.Q645R	EW-1	bone	COSMIC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.1389
p.G643D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0833
p.G643D	ACH-000888	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0833
p.G643D	NCI-H1793	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.0833
p.A650T	SIDM01609	Endometrial Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.2778
p.A650T	ACH-000972	Endometrial/Uterine Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	652:656	Mutation rewiring degron network	0.2778
p.S797T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VPSTPTST	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.6005
p.S797T	ACH-000912	Lung Cancer	CCLE	VPSTPTST	DEG_SCF_FBW7_1	791:798	Mutation altering degron motif	0.6005

Kaplan plot for PITPNM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITPNM1

UniProt ID: O00562

Entrez ID: 9600

Protein name: Membrane-associated phosphatidylinositol transfer protein 1 (Drosophila retinal degeneration B homolog) (Phosphatidylinositol transfer protein, membrane-associated 1) (PITPnm 1) (Pyk2 N-terminal domain-interacting receptor 2) (NIR-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITPNM1 in