DegronMD

Uniprot ID: O00562

Source protein: Membrane-associated phosphatidylinositol transfer protein 1

Source gene: PITPNM1

Class: DEG_SCF_FBW7_1

Location: 791:798

E3 ligase: FBXW7

DEGRON score: 0.7383

ASA_SCORE: 84.9

COIL: 0.9245

CONS_SCORE: 0.3571

DSS_SCORE: 0.4124

HELIX: 0.0445

FCONS_SCORE: 0.9404

RIG_SCORE: 0.6844

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T797N	DO229032	LICA	ICGC	VPSTPTST	DEG_SCF_FBW7_1	0.7055
p.L807S	DO25444	LUAD	ICGC	VPSTPTST	DEG_SCF_FBW7_1	0.0833
p.V790A	DO229211	THCA	ICGC	VPSTPTST	DEG_SCF_FBW7_1	0.3056
p.L786M	DO229245	THCA	ICGC	VPSTPTST	DEG_SCF_FBW7_1	0.1944
p.S797T	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	VPSTPTST	DEG_SCF_FBW7_1	0.6005
p.S797T	ACH-000912	Lung Cancer	CCLE	VPSTPTST	DEG_SCF_FBW7_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SCF_FBW7_1	791:798	VPSTPTST	FBXW7	0.7383	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons