DegronMD

Uniprot ID: O00562

Source protein: Membrane-associated phosphatidylinositol transfer protein 1

Source gene: PITPNM1

Class: DEG_SCF_FBW7_1

Location: 1221:1227

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 88.7143

COIL: 0.9623

CONS_SCORE: 0.382

DSS_SCORE: 0.8143

HELIX: 0.0189

FCONS_SCORE: 1.0628

RIG_SCORE: 0.587

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1221A	TCGA-35-4122	LUAD	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.7503
p.E1219K	TCGA-94-7943	LUSC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.2778
p.A1216V	TCGA-A6-5661	COAD	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.1944
p.R1230W	TCGA-AM-5821	COAD	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.25
p.R1234W	TCGA-B5-A3FC	UCEC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.1389
p.R1218C	TCGA-DX-A7EQ	SARC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.25
p.R1234L	TCGA-PG-A6IB	UCEC	TCGA	PGTPPTT	DEG_SCF_FBW7_1	0.1389
p.A1215V	DO8634	COAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.1667
p.R1229W	DO8240	COAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.2778
p.R1217H	DO223050	ESCA	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.2222
p.R1217H	DO233711	GACA	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.2222
p.P1220A	DO23782	LUAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.3056
p.E1218K	DO26475	LUSC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.25
p.R1217C	DO220032	SARC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.2222
p.S1213G	DO38376	STAD	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.1111
p.R1233L	DO52419	UCEC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.1667
p.R1233W	DO41871	UCEC	ICGC	PGTPPTT	DEG_SCF_FBW7_1	0.1667
p.P1221L	SIDM00831	Head and Neck Carcinoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM00206	Glioblastoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM01047	Chronic Myelogenous Leukemia	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM00095	Glioblastoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM00516	Melanoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM00176	Chondrosarcoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM00059	Ovarian Carcinoma	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471
p.P1221L	SIDM01879	Non-Cancerous	GDSC	PGTPPTT	DEG_SCF_FBW7_1	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SCF_FBW7_1	1221:1227	PGTPPTT	FBXW7	0.9968	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons