DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
PGTPPTT
Uniprot ID:
O00562
Source protein:
Membrane-associated phosphatidylinositol transfer protein 1
Source gene:
PITPNM1
Class:
DEG_SCF_FBW7_1
Location:
1221:1227
E3 ligase:
FBXW7
DEGRON score:
0.9968
ASA_SCORE:
88.7143
COIL:
0.9623
CONS_SCORE:
0.382
DSS_SCORE:
0.8143
HELIX:
0.0189
FCONS_SCORE:
1.0628
RIG_SCORE:
0.587
Degron related mutations and impact score
Show
10
25
50
100
entries
Search:
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P1221A
TCGA-35-4122
LUAD
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.7503
p.P1221L
SIDM00831
Head and Neck Carcinoma
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM00206
Glioblastoma
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM01047
Chronic Myelogenous Leukemia
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM00095
Glioblastoma
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM00516
Melanoma
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM00176
Chondrosarcoma
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM00059
Ovarian Carcinoma
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1221L
SIDM01879
Non-Cancerous
GDSC
PGTPPTT
DEG_SCF_FBW7_1
0.6471
p.P1220A
DO23782
LUAD
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.3056
p.E1219K
TCGA-94-7943
LUSC
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.2778
p.R1229W
DO8240
COAD
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.2778
p.R1230W
TCGA-AM-5821
COAD
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.25
p.R1218C
TCGA-DX-A7EQ
SARC
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.25
p.E1218K
DO26475
LUSC
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.25
p.R1217H
DO223050
ESCA
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.2222
p.R1217H
DO233711
GACA
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.2222
p.R1217C
DO220032
SARC
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.2222
p.A1216V
TCGA-A6-5661
COAD
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.1944
p.A1215V
DO8634
COAD
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.1667
p.R1233L
DO52419
UCEC
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.1667
p.R1233W
DO41871
UCEC
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.1667
p.R1234W
TCGA-B5-A3FC
UCEC
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.1389
p.R1234L
TCGA-PG-A6IB
UCEC
TCGA
PGTPPTT
DEG_SCF_FBW7_1
0.1389
p.S1213G
DO38376
STAD
ICGC
PGTPPTT
DEG_SCF_FBW7_1
0.1111
Showing 1 to 25 of 25 entries
Previous
1
Next
Drug responses associated with PITPNM1 mutations
Show
10
25
50
100
entries
Search:
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
No data available in table
Showing 0 to 0 of 0 entries
Previous
Next
All proteins holding degron of PGTPPTT
Show
10
25
50
100
entries
Search:
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00562
Membrane-associated phosphatidylinositol transfer protein 1
DEG_SCF_FBW7_1
1221:1227
PGTPPTT
FBXW7
0.9968
More...
Showing 1 to 1 of 1 entries
Previous
1
Next