DegronMD

Uniprot ID: O00562

Source protein: Membrane-associated phosphatidylinositol transfer protein 1

Source gene: PITPNM1

Class: DEG_SPOP_SBC_1

Location: 652:656

E3 ligase: SPOP

DEGRON score: 0.8499

ASA_SCORE: 71.76

COIL: 0.819

CONS_SCORE: 0.3685

DSS_SCORE: 0.7008

HELIX: 0.124

FCONS_SCORE: 0.9129

RIG_SCORE: 0.6162

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q645E	TCGA-A2-A0YK	BRCA	TCGA	PATTS	DEG_SPOP_SBC_1	0.1389
p.Q645E	DO2836	BRCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.S657F	TCGA-D3-A2JH	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.3056
p.S657F	DO47263	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.3056
p.E642K	TCGA-EO-A3KX	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	0.0556
p.E642K	DO219774	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	0.0556
p.R662Q	TCGA-F4-6856	COAD	TCGA	PATTS	DEG_SPOP_SBC_1	0.1667
p.R662Q	DO9114	COAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.1667
p.R662W	TCGA-F7-A624	HNSC	TCGA	PATTS	DEG_SPOP_SBC_1	0.1667
p.R662W	DO44440	HNSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.1667
p.E642D	SIDM00962	Chronic Myelogenous Leukemia	GDSC	PATTS	DEG_SPOP_SBC_1	0.0556
p.E642D	ACH-000432	Leukemia	CCLE	PATTS	DEG_SPOP_SBC_1	0.0556
p.E642D	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	PATTS	DEG_SPOP_SBC_1	0.0556
p.Q645R	SIDM00205	Ewing's Sarcoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.1389
p.Q645R	ACH-002110	Bone Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1389
p.Q645R	EW-1	bone	COSMIC	PATTS	DEG_SPOP_SBC_1	0.1389
p.G643D	SIDM00755	Non-Small Cell Lung Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.0833
p.G643D	ACH-000888	Lung Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.0833
p.G643D	NCI-H1793	lung	COSMIC	PATTS	DEG_SPOP_SBC_1	0.0833
p.A650T	SIDM01609	Endometrial Carcinoma	GDSC	PATTS	DEG_SPOP_SBC_1	0.2778
p.A650T	ACH-000972	Endometrial/Uterine Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SPOP_SBC_1	652:656	PATTS	SPOP	0.8499	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	460:464	PATTS	SPOP	0.9973	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	461:465	PATTS	SPOP	0.9422	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	111:115	PATTS	SPOP	0.9679	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	151:155	PATTS	SPOP	0.9788	More...
Q00535	Cyclin-dependent kinase 5	DEG_SPOP_SBC_1	243:247	PATTS	SPOP	0.9123	More...
Q12815	Tastin	DEG_SPOP_SBC_1	667:671	PATTS	SPOP	0.6469	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	523:527	PATTS	SPOP	0.9934	More...
Q2UY09	Collagen alpha-1	DEG_SPOP_SBC_1	1045:1049	PATTS	SPOP	0.9604	More...
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_SPOP_SBC_1	433:437	PATTS	SPOP	0.9972	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7103:7107	PATTS	SPOP	0.9088	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7978:7982	PATTS	SPOP	0.8819	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8273:8277	PATTS	SPOP	0.9418	More...
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	DEG_SPOP_SBC_1	169:173	PATTS	SPOP	0.9946	More...
Q99816	Tumor susceptibility gene 101 protein	DEG_SPOP_SBC_1	197:201	PATTS	SPOP	0.9804	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	98:102	PATTS	SPOP	0.8588	More...
Q9Y6R0	Numb-like protein	DEG_SPOP_SBC_1	266:270	PATTS	SPOP	0.9987	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1751:1755	PATTS	SPOP	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons