DegronMD - Q13585(GPR50)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D589E	TCGA-24-1843	OV	TCGA	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.D589E	DO29026	OV	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.25
p.D586E	TCGA-34-2604	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.D586E	DO26433	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.P529H	TCGA-75-7027	LUAD	TCGA	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2778
p.P529H	DO24811	LUAD	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2778
p.E514D	TCGA-A5-A0G1	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0833
p.E514D	DO42472	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0833
p.P590T	TCGA-AF-2691	READ	TCGA	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.P590T	TCGA-BR-8690	STAD	TCGA	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.P590T	DO36969	READ	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.P590T	DO47911	STAD	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.2778
p.A585T	TCGA-B5-A3FA	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1389
p.A585T	DO52402	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1389
p.P515T	TCGA-CD-8525	STAD	TCGA	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1111
p.P515T	DO47763	STAD	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1111
p.E514K	TCGA-EE-A3AA	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0833
p.E514K	DO37571	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.0833
p.P515L	TCGA-UF-A7J9	HNSC	TCGA	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1111
p.P515L	DO52111	HNSC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1111
p.T532A	DO228483	BRCA	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO229010	COCA	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO229005	COCA	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO229489	LAML	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO231140	LAML	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO229047	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO231067	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO231102	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.T532A	DO231155	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1944
p.A534S	DO229029	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.1389
p.I606V	DO230529	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.I606V	DO230993	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.I606V	DO230990	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.P521H	DO230971	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2778
p.P521H	DO224630	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation rewiring degron network	0.2778
p.P523T	DO50727	ORCA	ICGC	PATTS	DEG_SPOP_SBC_1	523:527	Mutation altering degron motif	0.7031
p.D582E	DO27877	ORCA	ICGC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.D582N	SIDM00216	Colorectal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.D582N	ACH-000989	Colon/Colorectal Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.D582N	SNU-175	large intestine	COSMIC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.0556
p.D586G	SIDM01045	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.D586G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667
p.D586G	EN	endometrium	COSMIC	VVTTS	DEG_SPOP_SBC_1	592:596	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GPR50

UniProt ID: Q13585

Entrez ID: 9248

Protein name: Melatonin-related receptor (G protein-coupled receptor 50) (H9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GPR50 in