DegronMD

Uniprot ID: Q13585

Source protein: Melatonin-related receptor

Source gene: GPR50

Class: DEG_SPOP_SBC_1

Location: 592:596

E3 ligase: SPOP

DEGRON score: 0.6486

ASA_SCORE: 61.46

COIL: 0.4464

CONS_SCORE: 0.2994

DSS_SCORE: 0.4924

HELIX: 0.0268

FCONS_SCORE: 0.9058

RIG_SCORE: 0.7407

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D589E	TCGA-24-1843	OV	TCGA	VVTTS	DEG_SPOP_SBC_1	0.25
p.D589E	DO29026	OV	ICGC	VVTTS	DEG_SPOP_SBC_1	0.25
p.D586E	TCGA-34-2604	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1667
p.D586E	DO26433	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1667
p.P590T	TCGA-AF-2691	READ	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2778
p.P590T	TCGA-BR-8690	STAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2778
p.P590T	DO36969	READ	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.P590T	DO47911	STAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.A585T	TCGA-B5-A3FA	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1389
p.A585T	DO52402	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.I606V	DO230529	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.I606V	DO230993	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.I606V	DO230990	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.D582E	DO27877	ORCA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.D582N	SIDM00216	Colorectal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.D582N	ACH-000989	Colon/Colorectal Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.0556
p.D582N	SNU-175	large_intestine	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.D586G	SIDM01045	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1667
p.D586G	ACH-000978	Endometrial/Uterine Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1667
p.D586G	EN	endometrium	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons