DegronMD - Q9NWB7(IFT57)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A6V	TCGA-B5-A5OC	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.A6V	DO52405	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.D15A	TCGA-CZ-4864	KIRC	TCGA	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.D15A	DO16178	KIRC	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.2222
p.V8L	TCGA-EK-A3GK	CESC	TCGA	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.5654
p.V8L	DO49964	CESC	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation altering degron motif	0.5654
p.A6D	DO228976	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.A6D	DO229037	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.A6D	DO229041	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.T2N	DO229018	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.G16R	DO222379	MELA	ICGC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.1944
p.G12A	SIDM00962	Chronic Myelogenous Leukemia	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.G12A	SIDM01261	Breast Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.G12A	SIDM00262	Ewing's Sarcoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.G12A	SIDM00477	Esophageal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.G12A	SIDM00539	Esophageal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.G12A	SIDM00314	Breast Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.G12A	SIDM01475	Ovarian Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.3056
p.E14K	SIDM00573	Glioblastoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.E14K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.E14K	ACH-000784	Esophageal Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.E14K	ACH-001606	Brain Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.E14K	no-11	central nervous system	COSMIC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25
p.E14K	KYSE-70	oesophagus	COSMIC	VVTTS	DEG_SPOP_SBC_1	7:11	Mutation rewiring degron network	0.25

Kaplan plot for IFT57 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IFT57

UniProt ID: Q9NWB7

Entrez ID: 55081

Protein name: Intraflagellar transport protein 57 homolog (Dermal papilla-derived protein 8) (Estrogen-related receptor beta-like protein 1) (HIP1-interacting protein) (MHS4R2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IFT57 in