DegronMD

Uniprot ID: Q9NWB7

Source protein: Intraflagellar transport protein 57 homolog

Source gene: IFT57

Class: DEG_SPOP_SBC_1

Location: 7:11

E3 ligase: SPOP

DEGRON score: 0.7919

ASA_SCORE: 93.06

COIL: 0.8834

CONS_SCORE: 0.1746

DSS_SCORE: 0.5043

HELIX: 0.0334

FCONS_SCORE: 0.9118

RIG_SCORE: 0.7948

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A6V	TCGA-B5-A5OC	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.3056
p.A6V	DO52405	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.D15A	TCGA-CZ-4864	KIRC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2222
p.D15A	DO16178	KIRC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2222
p.V8L	TCGA-EK-A3GK	CESC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.5654
p.V8L	DO49964	CESC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.5654
p.A6D	DO228976	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.A6D	DO229037	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.A6D	DO229041	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.T2N	DO229018	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.G16R	DO222379	MELA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.G12A	SIDM00962	Chronic Myelogenous Leukemia	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G12A	SIDM01261	Breast Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G12A	SIDM00262	Ewing's Sarcoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G12A	SIDM00477	Esophageal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G12A	SIDM00539	Esophageal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G12A	SIDM00314	Breast Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G12A	SIDM01475	Ovarian Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.E14K	SIDM00573	Glioblastoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.25
p.E14K	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.25
p.E14K	ACH-000784	Esophageal Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.25
p.E14K	ACH-001606	Brain Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.25
p.E14K	no-11	central_nervous_system	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.25
p.E14K	KYSE-70	oesophagus	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons