DegronMD - Q7L190(DPPA4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L185I	TCGA-34-5231	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.L185I	DO26772	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1111
p.L203M	TCGA-85-7699	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.L203M	DO26534	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1667
p.T183I	TCGA-98-A53I	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.T183I	DO219182	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.A207V	TCGA-AG-3592	READ	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.A207V	DO37308	READ	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.P199S	TCGA-B5-A3FC	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.P199S	DO41871	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.E200D	TCGA-BR-4368	STAD	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.E200D	DO38715	STAD	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.E200D	SIDM01729	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.25
p.T191P	TCGA-CV-7423	HNSC	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.T191P	DO14246	HNSC	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.2778
p.A204S	TCGA-G4-6588	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.A204S	DO10140	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.A207G	DO229047	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.0556
p.G188E	DO222405	MELA	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1944
p.A204V	DO229224	THCA	ICGC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.1389
p.V192G	SIDM01248	Thyroid Gland Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.V192G	ACH-001023	Thyroid Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056
p.V192G	CGTH-W-1	thyroid	COSMIC	VVTTS	DEG_SPOP_SBC_1	193:197	Mutation rewiring degron network	0.3056

Kaplan plot for DPPA4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DPPA4

UniProt ID: Q7L190

Entrez ID: 55211

Protein name: Developmental pluripotency-associated protein 4

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DPPA4 in