DegronMD

Uniprot ID: Q7L190

Source protein: Developmental pluripotency-associated protein 4

Source gene: DPPA4

Class: DEG_SPOP_SBC_1

Location: 193:197

E3 ligase: SPOP

DEGRON score: 0.7183

ASA_SCORE: 50.54

COIL: 0.4728

CONS_SCORE: 0.8769

DSS_SCORE: 0.2502

HELIX: 0.0146

FCONS_SCORE: 1.2494

RIG_SCORE: 0.8554

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L185I	TCGA-34-5231	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1111
p.L185I	DO26772	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.L203M	TCGA-85-7699	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1667
p.L203M	DO26534	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1667
p.T183I	TCGA-98-A53I	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0556
p.T183I	DO219182	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.A207V	TCGA-AG-3592	READ	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0556
p.A207V	DO37308	READ	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.P199S	TCGA-B5-A3FC	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2778
p.P199S	DO41871	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.E200D	TCGA-BR-4368	STAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.25
p.E200D	DO38715	STAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.25
p.E200D	SIDM01729	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.25
p.T191P	TCGA-CV-7423	HNSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2778
p.T191P	DO14246	HNSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.A204S	TCGA-G4-6588	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1389
p.A204S	DO10140	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.A207G	DO229047	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.G188E	DO222405	MELA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.A204V	DO229224	THCA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.V192G	SIDM01248	Thyroid Gland Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.V192G	ACH-001023	Thyroid Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.3056
p.V192G	CGTH-W-1	thyroid	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons