DegronMD - P48549(KCNJ3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D10E	TCGA-77-A5G3	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.D10E	DO45456	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.2222
p.V14L	TCGA-85-8049	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6765
p.V14L	DO26890	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.6765
p.G28W	TCGA-85-8288	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0556
p.G28W	DO26963	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0556
p.T17I	TCGA-AY-A54L	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7078
p.T17I	DO44091	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7078
p.D11N	TCGA-EE-A3J5	SKCM	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.25
p.D11N	DO47331	SKCM	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.25
p.R5Q	TCGA-EO-A22U	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.R5Q	TCGA-EO-A3B0	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.R5Q	DO219773	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.R5Q	DO43755	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.Q13H	TCGA-L4-A4E5	LUAD	TCGA	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.3056
p.Q13H	DO24320	LUAD	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.3056
p.G23V	DO229027	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.G28R	DO220913	MELA	ICGC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0556
p.T16A	SIDM00373	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation altering degron motif	0.7139
p.G23R	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.G23R	ACH-001363	Lung Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.G23R	NCI-H2135	lung	COSMIC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.1944
p.Q27K	SIDM01047	Chronic Myelogenous Leukemia	GDSC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.Q27K	ACH-000295	Leukemia	CCLE	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.Q27K	EM-2	haematopoietic and lymphoid tissue	COSMIC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.0833
p.G21V	SIDM00247	Gastric Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.25
p.G21V	ACH-000356	Gastric Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.25
p.G21V	MKN45	stomach	COSMIC	VVTTS	DEG_SPOP_SBC_1	14:18	Mutation rewiring degron network	0.25

Kaplan plot for KCNJ3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KCNJ3

UniProt ID: P48549

Entrez ID: 3760

Protein name: G protein-activated inward rectifier potassium channel 1 (GIRK-1) (Inward rectifier K(+) channel Kir3.1) (Potassium channel, inwardly rectifying subfamily J member 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KCNJ3 in