DegronMD

Uniprot ID: P48549

Source protein: G protein-activated inward rectifier potassium channel 1

Source gene: KCNJ3

Class: DEG_SPOP_SBC_1

Location: 14:18

E3 ligase: SPOP

DEGRON score: 0.9146

ASA_SCORE: 85.44

COIL: 0.7844

CONS_SCORE: 0.2453

DSS_SCORE: 0.5991

HELIX: 0.0384

FCONS_SCORE: 0.8712

RIG_SCORE: 0.7064

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D10E	TCGA-77-A5G3	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2222
p.D10E	DO45456	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2222
p.V14L	TCGA-85-8049	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.6765
p.V14L	DO26890	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.6765
p.G28W	TCGA-85-8288	LUSC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0556
p.G28W	DO26963	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.T17I	TCGA-AY-A54L	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.7078
p.T17I	DO44091	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.7078
p.D11N	TCGA-EE-A3J5	SKCM	TCGA	VVTTS	DEG_SPOP_SBC_1	0.25
p.D11N	DO47331	SKCM	ICGC	VVTTS	DEG_SPOP_SBC_1	0.25
p.R5Q	TCGA-EO-A22U	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0833
p.R5Q	TCGA-EO-A3B0	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0833
p.R5Q	DO219773	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0833
p.R5Q	DO43755	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0833
p.Q13H	TCGA-L4-A4E5	LUAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.3056
p.Q13H	DO24320	LUAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.G23V	DO229027	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.G28R	DO220913	MELA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.T16A	SIDM00373	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.7139
p.G23R	SIDM00700	Non-Small Cell Lung Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.G23R	ACH-001363	Lung Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1944
p.G23R	NCI-H2135	lung	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.Q27K	SIDM01047	Chronic Myelogenous Leukemia	GDSC	VVTTS	DEG_SPOP_SBC_1	0.0833
p.Q27K	ACH-000295	Leukemia	CCLE	VVTTS	DEG_SPOP_SBC_1	0.0833
p.Q27K	EM-2	haematopoietic_and_lymphoid_tissue	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.0833
p.G21V	SIDM00247	Gastric Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.25
p.G21V	ACH-000356	Gastric Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.25
p.G21V	MKN45	stomach	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTTS

Degron related mutations and impact score

Drug responses associated with KCNJ3 mutations

All proteins holding degron of VVTTS