DegronMD

Uniprot ID: Q5VUA4

Source protein: Zinc finger protein 318

Source gene: ZNF318

Class: DEG_SPOP_SBC_1

Location: 1339:1343

E3 ligase: SPOP

DEGRON score: 0.5532

ASA_SCORE: 89.74

COIL: 0.9074

CONS_SCORE: 0.2573

DSS_SCORE: 0.4851

HELIX: 0.0718

FCONS_SCORE: 0.9079

RIG_SCORE: 0.818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1335S	TCGA-26-1799	GBM	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2222
p.P1335S	DO11603	GBM	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2222
p.P1353S	TCGA-2W-A8YY	CESC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0556
p.P1353S	DO223732	CESC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0556
p.T1342A	TCGA-AA-3815	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.7139
p.T1342A	DO9924	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.7139
p.P1335H	TCGA-IB-7651	PAAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2222
p.P1335H	DO46657	PAAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2222
p.P1335R	DO222754	ESCA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2222
p.S1334R	DO232224	PBCA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons