DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 3981:3985

E3 ligase: SPOP

DEGRON score: 0.9671

ASA_SCORE: 83.7

COIL: 0.7864

CONS_SCORE: 0

DSS_SCORE: 0.4948

HELIX: 0.0166

FCONS_SCORE: 0

RIG_SCORE: 0.728

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K3976N	TCGA-AP-A059	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.3056
p.K3976N	DO41361	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.Q3989H	TCGA-BR-8485	STAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2222
p.Q3989H	DO47823	STAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2222
p.V3992A	TCGA-D3-A8GR	SKCM	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1389
p.V3992A	DO51247	SKCM	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.S3993Y	TCGA-E6-A1LX	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993Y	DO41020	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993Y	SIDM00193	Colorectal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993Y	ACH-000991	Colon/Colorectal Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993Y	SNU-81	large_intestine	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.E3988K	TCGA-FS-A1ZC	SKCM	TCGA	VVTTS	DEG_SPOP_SBC_1	0.25
p.E3988K	TCGA-FW-A3R5	SKCM	TCGA	VVTTS	DEG_SPOP_SBC_1	0.25
p.E3988K	DO37406	SKCM	ICGC	VVTTS	DEG_SPOP_SBC_1	0.25
p.E3988K	DO37487	SKCM	ICGC	VVTTS	DEG_SPOP_SBC_1	0.25
p.A3973V	TCGA-QH-A6X4	LGG	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1111
p.A3973V	DO50175	LGG	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993A	SIDM01183	Other Solid Cancers	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993A	ACH-001417	Lung Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3993A	UMC-11	lung	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.S3985F	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.9093
p.S3985F	SIDM00254	Neuroblastoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.9093
p.S3985F	SIDM00032	Bladder Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.9093
p.S3985F	SIDM00720	Mesothelioma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.9093
p.S3985F	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.9093
p.S3974P	SIDM01045	Endometrial Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.S3974P	ACH-000978	Endometrial/Uterine Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1389
p.S3974P	EN	endometrium	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.I3991M	SIDM00927	Small Cell Lung Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1667
p.I3991M	ACH-000871	Lung Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1667
p.I3991M	NCI-H510A	lung	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1667
p.S3979F	SIDM01727	Chronic Myelogenous Leukemia	GDSC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.S3979F	ACH-000241	Leukemia	CCLE	VVTTS	DEG_SPOP_SBC_1	0.2778
p.T3984A	SIDM01766	Chondrosarcoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VVTTS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of VVTTS