DegronMD

Uniprot ID: Q8IUR5

Source protein: Protein O-mannosyl-transferase TMTC1

Source gene: TMTC1

Class: DEG_SPOP_SBC_1

Location: 2:6

E3 ligase: SPOP

DEGRON score: 0.853

ASA_SCORE: 96.3

COIL: 0.818

CONS_SCORE: 0.23

DSS_SCORE: 0.8802

HELIX: 0.0784

FCONS_SCORE: 1.0315

RIG_SCORE: 0.785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H14Q	DO225028	BRCA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.N2T	DO3001	BRCA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.7055
p.P3L	DO44907	LIHC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.7582
p.R14S	DO224563	LUSC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.N2S	DO42280	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.7069
p.L13V	DO42793	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1389
p.C15Y	KP-1N	pancreas	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.0833
p.I11T	J82	urinary_tract	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.H14R	SNU-1040	large_intestine	COSMIC	VVTTS	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons