DegronMD

Uniprot ID: P85037

Source protein: Forkhead box protein K1

Source gene: FOXK1

Class: DEG_SPOP_SBC_1

Location: 527:531

E3 ligase: SPOP

DEGRON score: 0.6903

ASA_SCORE: 70.72

COIL: 0.7888

CONS_SCORE: 0.3533

DSS_SCORE: 0.2533

HELIX: 0.018

FCONS_SCORE: 0.9251

RIG_SCORE: 0.8645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V522I	TCGA-A6-6781	COAD	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1944
p.V522I	TCGA-OR-A5J5	ACC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1944
p.V522I	DO8447	COAD	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1944
p.V525I	TCGA-AP-A0LM	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2778
p.V525I	DO43306	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.Q518R	TCGA-BG-A222	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.0833
p.Q518R	DO42977	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.0833
p.V525G	TCGA-DD-A1EC	LIHC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.2778
p.V525G	DO22982	LIHC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.2778
p.T530I	TCGA-L5-A4OJ	ESCA	TCGA	VVTTS	DEG_SPOP_SBC_1	0.7078
p.A519P	TCGA-SL-A6JA	UCEC	TCGA	VVTTS	DEG_SPOP_SBC_1	0.1111
p.A519P	DO219787	UCEC	ICGC	VVTTS	DEG_SPOP_SBC_1	0.1111
p.A532S	DO229018	LICA	ICGC	VVTTS	DEG_SPOP_SBC_1	0.3056
p.S534L	SIDM00839	Colorectal Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.25
p.S534L	ACH-000950	Colon/Colorectal Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.25
p.G537R	SIDM01450	Gastric Carcinoma	GDSC	VVTTS	DEG_SPOP_SBC_1	0.1667
p.G537R	ACH-000898	Gastric Cancer	CCLE	VVTTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P48549	G protein-activated inward rectifier potassium channel 1	DEG_SPOP_SBC_1	14:18	VVTTS	SPOP	0.9146	More...
P85037	Forkhead box protein K1	DEG_SPOP_SBC_1	527:531	VVTTS	SPOP	0.6903	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	592:596	VVTTS	SPOP	0.6486	More...
Q5VUA4	Zinc finger protein 318	DEG_SPOP_SBC_1	1339:1343	VVTTS	SPOP	0.5532	More...
Q7L190	Developmental pluripotency-associated protein 4	DEG_SPOP_SBC_1	193:197	VVTTS	SPOP	0.7183	More...
Q8IUR5	Protein O-mannosyl-transferase TMTC1	DEG_SPOP_SBC_1	2:6	VVTTS	SPOP	0.853	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	3981:3985	VVTTS	SPOP	0.9671	More...
Q9NWB7	Intraflagellar transport protein 57 homolog	DEG_SPOP_SBC_1	7:11	VVTTS	SPOP	0.7919	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons