DegronMD

Uniprot ID: Q13585

Source protein: Melatonin-related receptor

Source gene: GPR50

Class: DEG_SPOP_SBC_1

Location: 523:527

E3 ligase: SPOP

DEGRON score: 0.9934

ASA_SCORE: 73.1

COIL: 0.8454

CONS_SCORE: 0.4548

DSS_SCORE: 0.721

HELIX: 0.0568

FCONS_SCORE: 1.1661

RIG_SCORE: 0.5847

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P529H	TCGA-75-7027	LUAD	TCGA	PATTS	DEG_SPOP_SBC_1	0.2778
p.P529H	DO24811	LUAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.2778
p.E514D	TCGA-A5-A0G1	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	0.0833
p.E514D	DO42472	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	0.0833
p.P515T	TCGA-CD-8525	STAD	TCGA	PATTS	DEG_SPOP_SBC_1	0.1111
p.P515T	DO47763	STAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.1111
p.E514K	TCGA-EE-A3AA	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.0833
p.E514K	DO37571	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.0833
p.P515L	TCGA-UF-A7J9	HNSC	TCGA	PATTS	DEG_SPOP_SBC_1	0.1111
p.P515L	DO52111	HNSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.1111
p.T532A	DO228483	BRCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO229010	COCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO229005	COCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO229489	LAML	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO231140	LAML	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO229047	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO231067	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO231102	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.T532A	DO231155	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.1944
p.A534S	DO229029	LICA	ICGC	PATTS	DEG_SPOP_SBC_1	0.1389
p.P521H	DO230971	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.2778
p.P521H	DO224630	LUSC	ICGC	PATTS	DEG_SPOP_SBC_1	0.2778
p.P523T	DO50727	ORCA	ICGC	PATTS	DEG_SPOP_SBC_1	0.7031

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SPOP_SBC_1	652:656	PATTS	SPOP	0.8499	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	460:464	PATTS	SPOP	0.9973	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	461:465	PATTS	SPOP	0.9422	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	111:115	PATTS	SPOP	0.9679	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	151:155	PATTS	SPOP	0.9788	More...
Q00535	Cyclin-dependent kinase 5	DEG_SPOP_SBC_1	243:247	PATTS	SPOP	0.9123	More...
Q12815	Tastin	DEG_SPOP_SBC_1	667:671	PATTS	SPOP	0.6469	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	523:527	PATTS	SPOP	0.9934	More...
Q2UY09	Collagen alpha-1	DEG_SPOP_SBC_1	1045:1049	PATTS	SPOP	0.9604	More...
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_SPOP_SBC_1	433:437	PATTS	SPOP	0.9972	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7103:7107	PATTS	SPOP	0.9088	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7978:7982	PATTS	SPOP	0.8819	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8273:8277	PATTS	SPOP	0.9418	More...
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	DEG_SPOP_SBC_1	169:173	PATTS	SPOP	0.9946	More...
Q99816	Tumor susceptibility gene 101 protein	DEG_SPOP_SBC_1	197:201	PATTS	SPOP	0.9804	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	98:102	PATTS	SPOP	0.8588	More...
Q9Y6R0	Numb-like protein	DEG_SPOP_SBC_1	266:270	PATTS	SPOP	0.9987	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1751:1755	PATTS	SPOP	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons