DegronMD

Uniprot ID: Q00535

Source protein: Cyclin-dependent kinase 5

Source gene: CDK5

Class: DEG_SPOP_SBC_1

Location: 243:247

E3 ligase: SPOP

DEGRON score: 0.9123

ASA_SCORE: 68.86

COIL: 0.9072

CONS_SCORE: 0.4098

DSS_SCORE: 0.2466

HELIX: 0.0532

FCONS_SCORE: 0.779

RIG_SCORE: 0.7868

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V249E	TCGA-55-8207	LUAD	TCGA	PATTS	DEG_SPOP_SBC_1	0.2778
p.V249E	DO45351	LUAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.2778
p.A244T	TCGA-AX-A1CE	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	0.6028
p.A244T	DO42280	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	0.6028
p.P240L	TCGA-D3-A3ML	SKCM	TCGA	PATTS	DEG_SPOP_SBC_1	0.25
p.P240L	DO47413	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	0.25
p.P240L	ACH-000398	Lymphoma	CCLE	PATTS	DEG_SPOP_SBC_1	0.25
p.K237N	TCGA-EY-A215	UCEC	TCGA	PATTS	DEG_SPOP_SBC_1	0.6111
p.K237N	DO42665	UCEC	ICGC	PATTS	DEG_SPOP_SBC_1	0.6111
p.D235G	DO233550	PRAD	ICGC	PATTS	DEG_SPOP_SBC_1	0.1111
p.V252A	ACH-000591	Brain Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	0.1944
p.A248T	Sarc9371	bone	COSMIC	PATTS	DEG_SPOP_SBC_1	0.3056

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01188	PAAD\|pancreas	p.R120C (No)	GDSC	PHA-793887	6.4871
SIDM01188	PAAD\|pancreas	p.R120C (No)	GDSC	Dinaciclib	1.3741
SIDM01259	ALL\|lymphoblastic_leukemia	p.K75fs*7 (No)	GDSC	CGP-60474	0.3185
SIDM01259	ALL\|lymphoblastic_leukemia	p.K75fs*7 (No)	GDSC	PHA-793887	0.4854
SIDM01259	ALL\|lymphoblastic_leukemia	p.K75fs*7 (No)	GDSC	Dinaciclib	0.1399
SIDM01045	UCEC\|endometrium	p.L165M (No)	GDSC	PHA-793887	14.3685
SIDM01045	UCEC\|endometrium	p.L165M (No)	GDSC	Dinaciclib	0.0365
SIDM00217	COREAD\|large_intestine	p.T231A (No)	GDSC	PHA-793887	2.7884
SIDM00217	COREAD\|large_intestine	p.T231A (No)	GDSC	Dinaciclib	0.0529
SIDM00217	COREAD\|large_intestine	p.R200W (No)	GDSC	PHA-793887	2.7884
SIDM00217	COREAD\|large_intestine	p.R200W (No)	GDSC	Dinaciclib	0.0529
SIDM00363	LAML\|acute_myeloid_leukaemia	p.G138W (No)	GDSC	CGP-60474	0.669
SIDM00363	LAML\|acute_myeloid_leukaemia	p.G138W (No)	GDSC	PHA-793887	5.3835
SIDM00789	COREAD\|large_intestine	p.G138E (No)	GDSC	PHA-793887	164.3388
SIDM00789	COREAD\|large_intestine	p.G138E (No)	GDSC	Dinaciclib	0.0351
SIDM00789	COREAD\|large_intestine	p.K56N (No)	GDSC	PHA-793887	164.3388
SIDM00789	COREAD\|large_intestine	p.K56N (No)	GDSC	Dinaciclib	0.0351
SIDM00317	KIRC\|kidney	p.R120C (No)	GDSC	PHA-793887	28.3314
SIDM00317	KIRC\|kidney	p.R120C (No)	GDSC	Dinaciclib	1.1202
SIDM00373	UCEC\|endometrium	p.R149* (No)	GDSC	PHA-793887	1.3201
SIDM00373	UCEC\|endometrium	p.R149* (No)	GDSC	Dinaciclib	0.0256

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00562	Membrane-associated phosphatidylinositol transfer protein 1	DEG_SPOP_SBC_1	652:656	PATTS	SPOP	0.8499	More...
P08651	Nuclear factor 1 C-type	DEG_SPOP_SBC_1	460:464	PATTS	SPOP	0.9973	More...
P18146	Early growth response protein 1	DEG_SPOP_SBC_1	461:465	PATTS	SPOP	0.9422	More...
P34810	Macrosialin	DEG_SPOP_SBC_1	111:115	PATTS	SPOP	0.9679	More...
P37198	Nuclear pore glycoprotein p62	DEG_SPOP_SBC_1	151:155	PATTS	SPOP	0.9788	More...
Q00535	Cyclin-dependent kinase 5	DEG_SPOP_SBC_1	243:247	PATTS	SPOP	0.9123	More...
Q12815	Tastin	DEG_SPOP_SBC_1	667:671	PATTS	SPOP	0.6469	More...
Q13585	Melatonin-related receptor	DEG_SPOP_SBC_1	523:527	PATTS	SPOP	0.9934	More...
Q2UY09	Collagen alpha-1	DEG_SPOP_SBC_1	1045:1049	PATTS	SPOP	0.9604	More...
Q68D85	Natural cytotoxicity triggering receptor 3 ligand 1	DEG_SPOP_SBC_1	433:437	PATTS	SPOP	0.9972	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7103:7107	PATTS	SPOP	0.9088	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	7978:7982	PATTS	SPOP	0.8819	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	8273:8277	PATTS	SPOP	0.9418	More...
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	DEG_SPOP_SBC_1	169:173	PATTS	SPOP	0.9946	More...
Q99816	Tumor susceptibility gene 101 protein	DEG_SPOP_SBC_1	197:201	PATTS	SPOP	0.9804	More...
Q9BVL2	Nucleoporin p58/p45	DEG_SPOP_SBC_1	98:102	PATTS	SPOP	0.8588	More...
Q9Y6R0	Numb-like protein	DEG_SPOP_SBC_1	266:270	PATTS	SPOP	0.9987	More...
Q5HYC2	Uncharacterized protein KIAA2026	DEG_SPOP_SBC_1	1751:1755	PATTS	SPOP	0.9429	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons