DegronMD - Q9Y6R0(NUMBL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A582V	TCGA-CK-6746	COAD	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	577:584	Mutation altering degron motif	0.5825
p.A582V	DO224768	BRCA	ICGC	FEAQWAAL	DEG_MDM2_SWIB_1	577:584	Mutation altering degron motif	0.5825
p.A582V	DO7938	COAD	ICGC	FEAQWAAL	DEG_MDM2_SWIB_1	577:584	Mutation altering degron motif	0.5825
p.R280W	DO10859	ESAD	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.R280W	DO233898	GACA	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.Q262L	DO228206	LICA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.7765
p.P256S	DO220906	MELA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1667
p.P256S	DO220906	MELA	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.0556
p.S276L	DO222775	MELA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.S276L	DO222775	MELA	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.S276L	DO47665	SKCM	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1389
p.S276L	DO47665	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1667
p.R266C	DO27945	ORCA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.8301
p.R266C	DO27945	ORCA	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation altering degron motif	0.8301
p.P264L	DO32878	PACA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation altering degron motif	0.6471
p.P277L	DO219464	SKCM	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.1111
p.P277L	DO219464	SKCM	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1389
p.P271T	DO229216	THCA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2778
p.P271T	DO229216	THCA	ICGC	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.3056
p.A253S	SIDM02050	Colorectal Carcinoma	GDSC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0833
p.G586S	SIDM00303	Ovarian Carcinoma	GDSC	FEAQWAAL	DEG_MDM2_SWIB_1	577:584	Mutation rewiring degron network	0.2778
p.G586S	ACH-000584	Ovarian Cancer	CCLE	FEAQWAAL	DEG_MDM2_SWIB_1	577:584	Mutation rewiring degron network	0.2778
p.Q258P	ACH-000704	Ovarian Cancer	CCLE	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.2222
p.Q258P	ACH-000704	Ovarian Cancer	CCLE	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1111
p.H261L	ACH-000983	Leukemia	CCLE	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.3056
p.H261L	ACH-000983	Leukemia	CCLE	PATTS	DEG_SPOP_SBC_1	266:270	Mutation rewiring degron network	0.1944
p.R252H	SNU-1040	large intestine	COSMIC	VSPTPATT	DEG_SCF_FBW7_1	262:269	Mutation rewiring degron network	0.0556

Kaplan plot for NUMBL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NUMBL

UniProt ID: Q9Y6R0

Entrez ID: 9253

Protein name: Numb-like protein (Numb-related protein) (Numb-R)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NUMBL in