DegronMD

Uniprot ID: Q9Y6R0

Source protein: Numb-like protein

Source gene: NUMBL

Class: DEG_SCF_FBW7_1

Location: 262:269

E3 ligase: FBXW7

DEGRON score: 0.9987

ASA_SCORE: 82.5625

COIL: 0.9378

CONS_SCORE: 0.4168

DSS_SCORE: 0.8086

HELIX: 0.0146

FCONS_SCORE: 1.352

RIG_SCORE: 0.5752

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R266C	DO27945	ORCA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.8301
p.Q262L	DO228206	LICA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.7765
p.P264L	DO32878	PACA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.6471
p.H261L	ACH-000983	Leukemia	CCLE	VSPTPATT	DEG_SCF_FBW7_1	0.3056
p.P271T	DO229216	THCA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.2778
p.Q258P	ACH-000704	Ovarian Cancer	CCLE	VSPTPATT	DEG_SCF_FBW7_1	0.2222
p.P256S	DO220906	MELA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.1667
p.S276L	DO222775	MELA	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.1389
p.S276L	DO47665	SKCM	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.1389
p.P277L	DO219464	SKCM	ICGC	VSPTPATT	DEG_SCF_FBW7_1	0.1111
p.A253S	SIDM02050	Colorectal Carcinoma	GDSC	VSPTPATT	DEG_SCF_FBW7_1	0.0833
p.R252H	SNU-1040	large_intestine	COSMIC	VSPTPATT	DEG_SCF_FBW7_1	0.0556

Showing 1 to 12 of 12 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y6R0	Numb-like protein	DEG_SCF_FBW7_1	262:269	VSPTPATT	FBXW7	0.9987	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons