DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
VSPTPATT
Uniprot ID:
Q9Y6R0
Source protein:
Numb-like protein
Source gene:
NUMBL
Class:
DEG_SCF_FBW7_1
Location:
262:269
E3 ligase:
FBXW7
DEGRON score:
0.9987
ASA_SCORE:
82.5625
COIL:
0.9378
CONS_SCORE:
0.4168
DSS_SCORE:
0.8086
HELIX:
0.0146
FCONS_SCORE:
1.352
RIG_SCORE:
0.5752
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.Q262L
DO228206
LICA
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.7765
p.P256S
DO220906
MELA
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.1667
p.S276L
DO222775
MELA
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.1389
p.S276L
DO47665
SKCM
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.1389
p.R266C
DO27945
ORCA
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.8301
p.P264L
DO32878
PACA
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.6471
p.P277L
DO219464
SKCM
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.1111
p.P271T
DO229216
THCA
ICGC
VSPTPATT
DEG_SCF_FBW7_1
0.2778
p.A253S
SIDM02050
Colorectal Carcinoma
GDSC
VSPTPATT
DEG_SCF_FBW7_1
0.0833
p.Q258P
ACH-000704
Ovarian Cancer
CCLE
VSPTPATT
DEG_SCF_FBW7_1
0.2222
p.H261L
ACH-000983
Leukemia
CCLE
VSPTPATT
DEG_SCF_FBW7_1
0.3056
p.R252H
SNU-1040
large_intestine
COSMIC
VSPTPATT
DEG_SCF_FBW7_1
0.0556
Drug responses associated with NUMBL mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VSPTPATT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y6R0
Numb-like protein
DEG_SCF_FBW7_1
262:269
VSPTPATT
FBXW7
0.9987
More...