DegronMD

Uniprot ID: Q9Y6R0

Source protein: Numb-like protein

Source gene: NUMBL

Class: DEG_MDM2_SWIB_1

Location: 577:584

E3 ligase: MDM2

DEGRON score: 0.9709

ASA_SCORE: 64.75

COIL: 0.3453

CONS_SCORE: 0.3951

DSS_SCORE: 0.5962

HELIX: 0.6384

FCONS_SCORE: 1.1622

RIG_SCORE: 0.764

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A582V	TCGA-CK-6746	COAD	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	0.5825
p.A582V	DO224768	BRCA	ICGC	FEAQWAAL	DEG_MDM2_SWIB_1	0.5825
p.A582V	DO7938	COAD	ICGC	FEAQWAAL	DEG_MDM2_SWIB_1	0.5825
p.G586S	SIDM00303	Ovarian Carcinoma	GDSC	FEAQWAAL	DEG_MDM2_SWIB_1	0.2778
p.G586S	ACH-000584	Ovarian Cancer	CCLE	FEAQWAAL	DEG_MDM2_SWIB_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons