DegronMD

Uniprot ID: P49757

Source protein: Protein numb homolog

Source gene: NUMB

Class: DEG_MDM2_SWIB_1

Location: 616:623

E3 ligase: MDM2

DEGRON score: 0.9869

ASA_SCORE: 52.2125

COIL: 0.0671

CONS_SCORE: 0.3927

DSS_SCORE: 0.5237

HELIX: 0.9264

FCONS_SCORE: 1.186

RIG_SCORE: 0.8011

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P633S	TCGA-13-0791	OV	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	0.0556
p.R630H	TCGA-AX-A2HD	UCEC	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	0.1389
p.R630H	SIDM01181	Hepatocellular Carcinoma	GDSC	FEAQWAAL	DEG_MDM2_SWIB_1	0.1389
p.R630H	SNU-398	liver	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.1389
p.K626Q	TCGA-D8-A1JP	BRCA	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	0.3611
p.S627F	TCGA-W3-AA1R	SKCM	TCGA	FEAQWAAL	DEG_MDM2_SWIB_1	0.2222
p.A622V	SIDM01169	Ovarian Carcinoma	GDSC	FEAQWAAL	DEG_MDM2_SWIB_1	0.5825
p.A622V	TOV-21G	ovary	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.5825
p.A611V	TOV-21G	ovary	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.1944
p.S629F	KYSE-510	oesophagus	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.1667
p.T631S	NCI-H1092	lung	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.5556
p.R619H	SNU-398	liver	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.8244
p.T620S	NCI-H1092	lung	COSMIC	FEAQWAAL	DEG_MDM2_SWIB_1	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons